Crude oil, which is a primary source of energy for human civilization, predicted to rule the world even in the coming decades. India being the third largest consumer of crude oil, imports 82% of its oil needs from other countries. In the near future, India has plans to bring down the net crude oil import to 67% by implementing local exploration and renewable energy. However, due to the high capital cost, resource location and quality issues, the renewable energy is not ready to replace the market of crude oil at the instant, and also the exploration of local reserves for crude oil production seems to be scare. Thus the increase in energy demand has stressed the oil and gas companies to exploit each reservoir till reaching its maximum productivity and high recovery factor. The successive use of primary recovery and secondary recovery technique approximately displaces only about 15% to 50% of the original oil in place (OOIP). The remaining residual oil left behind the reservoir after primary and secondary technique is the target for tertiary (or) enhanced oil recovery (EOR) operation. Low salinity water (LSW) flooding has developed as a new cost effective and environmental friendly EOR technique. However, the inability of the process to show a significant improvement in the IFT reduction opens to a new area of research by adding certain additives. The role of alkaline flooding to alter the rock wettability as well as interfacial tension (IFT) is inevitable in EOR. However, the need for high amount of alkaline makes the process economically unjustified. On the other hand, nanoparticles are currently gaining wide acceptance in the field of petroleum engineering. The injection of nanoparticles as nanofluids into the reservoir is more effective than water injection but not as chemical flooding. In this study, the effect of alkali and lowsal-alkali on the IFT of various hydrocarbons and crude oil is investigated at different temperature. Further, the effect of these recovery agents on the wettability of quartz surface is investigated. The performance of nanofluid in EOR is evaluated through Amott cell by following spontaneous imbibition oil recovery. We observed that the nanofluid produced by the synergistic effect of alkali, silica nanoparticles and low salinity water could effectively reduce interfacial tension of low acidic number crude oil and increases the recovery by 40%.