In recent days, the presence of pharmaceuticals and personal care products (PPCPs) are being reported in various environmental matrices. It causes multiple pernicious effects on the ecosystem. Most of the rural and peri-urban areas in developing countries lack wastewater treatment facilities, and the advanced treatment technologies to eliminate PPCPs, incur exorbitant costs and energy requirements. Consequently, constructed wetland systems (CWs) can be a cost-effective and efficient treatment process. This seminar discusses the potential of each component of CWs (plants, substrate materials, and microbes) for PPCPs removal through batch laboratory studies. In batch hydroponics studies, C. indica demonstrated significantly higher specific uptake potential (10.72 to 14.16 mg/g) of PPCPs than C. zizanioides (5.27 to 7.57 mg/g). The biodegradation studies with the acclimatized microbes (identified as Proteobacteria, Sphingobacteria, Arcobacter, Actinobacteria, and Chryseobacteria) showed effective degradation of PPCPs under different redox conditions. The adsorption breakthrough studies with four substrate materials showed their sorption capacities as natural zeolite (1.6-2.15µg/g) light-weight expanded clay aggregates (5.37-8.27µg/g) waste autoclaved aerated concrete (AAC) block (9.27-10.79µg/g) wood charcoal (24.10-26.40µg/g), according to their surface and textural properties. Four laboratory-scale CW units with enriched microbes, C. indica, and supporting materials were monitored to remove organics, nutrients, and PPCPs. Eventually, the synergistic combination of AAC, enriched microbes, and C. indica notably witnessed an enhanced removal of pollutants. In addition, the distribution of various PPCPs in rural wastewater and their fate in the field-scale wetland system were explored. Among the investigated 14 PPCPs, caffeine, triclosan, bisphenol A, and diethyl phthalate were detected most frequently (5 ng/L to 250.14 µg/L) in the wastewater. The overall removal efficiencies of COD, ammonia, phosphate, pathogens, and PPCPs were found to be 93.34%, 85.25%, 79.81%, 99.90%, and 89.30%, respectively. The reuse of treated effluent was a low risk to human and aquatic organisms. Thus, CWs could effectively eliminate the PPCPs and curtail the environmental risk.