The purpose of this lecture is to outline the state of the art and open questions in the research fields dealing with drops, sprays and wetting phenomena. Specifically it highlights the research pursued at TU Darmstadt, in an effort to identify areas of common interest with faculty at IIT-Madras and to promote further cooperation in the scope of the Henry Ford Chair appointment. Topics to be addressed include the impact of drops and supercooled large drops (SLD) on heated and/or cooled surfaces, leading to cooling of, or solidification and ice accretion on substrates of various complexity. The challenges in transitioning from single drop phenomena to sprays and impinging sprays will then be discussed, with special emphasis on mechanisms of atomization and the possibility of modelling and simulating atomization and spray phenomena. Finally, wetting phenomena will be introduced, outlining its central role in a large number of practical engineering systems. These topics will be discussed in terms of analytic, experimental and numerical simulations approaches. Given the enormous scope of these topics, the lecture will be more superficial in nature, anticipating subsequent and more detailed interactions in the future. The lecture will close with a brief overview of other research areas that might offer potential for cooperation, specifically advanced measurement techniques in fluid mechanics and unsteady aerodynamics.