Cell culture is a random phenomenon with no control over its spatial and temporal aspects as well as distribution of population density. This makes operations such as live cell tracing, isolation, targeted stimulation and delivery for downstream analysis very difficult. Micro electro mechanical systems (MEMS) are thus designed to control the spatial distribution of cells over the substrate in its live culture. MEMS make use of microfabrication technology along with concepts of energy, chemistry, physics and mechanics to manipulate cells with up to single cell precision. Here, we will discuss the micro contact printing technique used to chemically modify cell culture substrates. This induces formation of cell patterns on culture substrates for better accessibility to investigate individual cells and their inter-cellular interactions. The cell patterning gives high spatial resolution without unnecessary inference from unwanted chemicals. The microfabrication processes of micro contact printing technology and the cell pattern obtained after pattern printing is discussed in detail. The technique is easy and cheap to fabricate as compared to other known techniques. Once micro stamps are fabricated, they can be easily incorporated in biological lab experiments without the need of sophisticated instruments. This technology can especially be beneficial in the research of regenerative medicine and tissue engineering. The increase in ease and accessibility to technology used for the study of individual cells can revolutionize personalized medicine.