Department of Chemistry
Indian Institute of Technology Madras, Chennai-600036

Research Proposal Seminar
Development of New Synthetic Methods in Green Reaction Medium
Name: Ashish Chander Satti (CY20D091) Date: 19-09-2023
Guide: Prof. S. Baskaran Time: 4:00 PM
Venue: CB310, Department of Chemistry
Abstract: Green chemistry is defined as the design and implementation of a chemical process that can eliminate or reduces the use of solvents and reagents that are hazardous to human health and environment.1 In 1998, Paul Anastas has introduced the principles of green chemistry, focusing on the environmental impact of chemical reaction and waste generation. The major principles of green chemistry are design and development of catalytic methods, use of renewable resources and pollution prevention.2 Moreover, use of organic solvents have contributed to air, water and soil pollution. To address these issues, volatile organic solvents are being replaced with renewable and environmental benign alternative solvents. Consequently, many green solvents have been recognized and their applications in green synthesis have been explored.3 Intriguingly, low melting mixtures are environmentally benign and, readily renewable and biodegradable reaction medium.4
Scheme 1. One-pot synthesis of biologically important scaffolds in low melting mixture

In this presentation, using of low melting mixture as a novel green reaction medium, development of new synthetic methods in organic synthesis will be discussed.

References:
1. (a) Horvath, I. T.; Anastas, P. T. Chem. Soc. Rev., 2007, 107, 2167-2168. (b) Kar, S.; Sanderson, H.; Roy, K.; Benfenati, E.; Leszczynski, J. Chem. Soc. Rev., 2021, 122, 3637-3710.
2. Anastas, P.; Eghbali, N. Chem. Soc. Rev., 2010, 39, 301-312.
3. (a) Zhang, Q.; Vigier, K. D. O.; Royer, S.; Jerome, F. Chem. Soc. Rev., 2012, 41, 7108-7146. (b) Hansen, B. B.; Spittle, S.; Chen, B.; Poe, D.; Zhang, Y.; Klein, J. M.; Sangoro, J. R. Chem. Rev., 2021, 121, 1232-1285.
4. (a) Devi, P.; Lambu, M. R.; Baskaran, S. Org. Biomol. Chem., 2020, 18, 4164–4168. (b) Gore, S.; Baskaran, S.; Koenig, B. Adv. Synth. Catal., 2012, 354, 2368 – 2372.