Abstract: Multicomponent reactions (MCRs) are chemical transformations in which three or more reactants are combined in a sequential manner to give highly selective products. This methodology has been proved as a powerful approach for the rapid and modular generation of molecular complexity via a step and atom economic manner.1 Over the past few decades, transition metal–catalysed C–H bond functionalisation has garnered a great deal of attention in the field of synthetic organic chemistry and has been widely applied in fields from drug discovery to material science.2,3 In recent years, sequential three-component C–H bond addition across π-bond isosteres followed by coupling with different functionalities has been evolved as a prominent field of research. In this transformation the metallacycle formed upon initial reaction with the first coupling partner is intercepted by reaction with the second coupling partner before undergoing typical termination processes such as reductive elimination, β-hydride elimination or protodemetalation. The diversity of mechanisms that have been elucidated for these transformations is one of the most fascinating aspects of this research area.4 This strategy includes simple chemical inputs with mild reaction conditions, which leads to diversity-oriented synthesis of complex molecular scaffolds. In this research proposal seminar, a thorough literature review of transition metal-catalysed three component sequential C-H bond addition cascade will be discussed and a future prospective in Co(III)- Catalysed three component cascade synthesis will be presented.5,6

References:
[1] Ugi, I.; Domling, A. Angew. Chem. Int. Ed. 2000, 39, 3168.
[2] Gensch, T.; Hopkinson, M. N.; Glorius, F.; Wencel-Delord, J. Chem. Soc. Rev. 2016, 45, 2900.
[3] Song, G.; Wang, F.; Li, X. Chem. Soc. Rev. 2012, 41, 3651.
[4] Brandes, D. S.; Ellman, J. A. Chem. Soc. Rev. 2022, 51, 6738.
[5] Prusty, P.; Jeganmohan, M. Chem. Commun. 2023, 59, 7216.
[6] Prusty, P.; Jeganmohan, M. Org. Lett. 2022, 24, 5, 1121.