Department of Chemistry
Indian Institute of Technology Madras, Chennai-600036

Research Proposal Seminar
Palladium-Catalyzed Functionalization of Unactivated C(sp3)-H Bonds

Name: Ananya Dutta Date & Time: 19-09-2023 & 3 pm
Guide: Prof. M. Jeganmohan Venue: CB310, Seminar Hall, Department of Chemistry
Abstract: The C(sp3)-H functionalization has progressively been developed into a powerful synthetic tool for the synthesis of many pharmaceutically and biologically important molecules. This type of functionalization faces a lot of challenges as C(sp3)-H bonds are ubiquitous in organic molecules and are difficult to differentiate.1 Among all the other types of CH linkages, aliphatic C(sp3)−H bonds are the most difficult bonds to cleave. The inertness of aliphatic C(sp3)H bonds arises from its inherent properties like high bond dissociation energy, low acidity, added conformational degrees of freedom and lack of π-assistance.2 The only strategy to address this issue is directing group assisted transition-metal catalyzed CH bond activation, where an exogenous group or native directing group orients the transition metal catalyst towards a particular CH bond in a highly selective manner.3 In this research proposal seminar, a comprehensive survey on various directing group assisted Pd-metal catalyzed C(sp3 )−H functionalization via CH activation will be discussed.

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2. (a) Ni, S. F.; Huang, G.; Chen, Y.; Wright, J. S.; Li, M.; Dang, Li. Coordination Chemistry Reviews. 2022, 455, 214255. (b) Liu, B.; Romine, A. M.; Rubel, C. Z.; Engle, K. M.; Shi, B. F. Chem. Rev. 2021, 121, 14957-15074. (c) Li, H.; Li, B. F.; Shi, Z. J. Catal. Sci. Technol. 2011, 1, 191–206.
3. (a) Zhang, Q.; Shi, B. F. Chem. Sci. 2021, 12, 841. (b) Dutta, S.; Bhattacharya, T.; Geffers, F. J.; Burger, M.; Maiti, D.; Werz, D. B. Chem. Sci. 2022, 13, 2551.