Dehumidifying air in space conditioning systems is an essential requirement to improve thermal comfort for the occupants. According to ASHRAE, dry bulb temperatures between 23 ℃ - 27 ℃ and relative humidity between 30% and 65% are considered comfort conditions during summer. With the increase in the standard of living and affluence worldwide, the demand for air conditioning is increasing rapidly, especially in hot and humid climates. Vapour compression system (VCS) is the technology of choice in hot and humid environments for space conditioning. This system addresses the latent heat load in dehumidification by cooling air below the dew point temperature. In humid conditions, removal of moisture is very energy-intensive and does not benefit much from current advancements such as inverter systems, as these are very effective mainly for sensible cooling. Solid desiccants along with VCS have evolved as a solution which is known as the hybrid cooling system (HCS). In HCS, dehumidification is accomplished using the desiccant wheel, and sensible cooling is achieved using the VCS, thus decoupling the sensible and the latent loads. But, natural gas-fired boilers or electric heaters are used to regenerate the water absorbed by the desiccant, which makes the system inefficient and dependent on primary fuels, moving away from CO2 reduction efforts. The objective of the thesis is to improve the performance of the HCS by adopting heat pumps to regenerate the water absorbed by the desiccant wheel and propose new architectures that involve evaporative coolers