Water scarcity and water pollution are pressing issues in the world. Industrialization, urbanization, climate change, high consumption rate are the key factors for increased discharge of wastewater in the natural water bodies that pose a detrimental risk to the ecosystem. Moreover, the wastewater generated is enriched with contaminants of emerging concerns like antibiotics and nutrients (nitrates and phosphates). The presence of these pollutants in the aquatic environment adversely impacts biodiversity and causes the development of antibiotic-resistant genes. Thus, there is an urgent need to remove antibiotics and nutrients from wastewater. Conventional treatment technologies such as activated sludge process (ASP) and advanced oxidation processes have been used for antibiotics and nutrient removal. However, these are limited due to inefficiency in removal (ASP), higher costs, and production of toxic by-products. Microalgal-bacterial systems have been proven effective for antibiotics and nutrient removal from wastewater. The synergistic effect of algae and bacteria improves biomass production and reduces aeration requirement, carbon footprint & cost by >50%. Accordingly, the objective of this study is to assess the performance of the microalgae-bacteria system for the removal of antibiotics and nutrients along with analysing the changes in antibiotic resistance profile post-treatment. Also, it will provide insight into the reusability of treated effluent and used biomass to establish the concept of the circular economy.