A study has been conducted to understand the differences in failure behaviour of a carbon fiber reinforced plastic (CFRP) material fabricated in two different laminate sequences. The material chosen was AS4 with the laminate systems as (0/45/-45/90) and (0/90/45/-45), both of quasi-isotropic (QI) nature. Carefully fabricated test coupons were tested under tensile, compression, flexure and impact load conditions. The tensile and compression test results did not show any influence of the laminate system. However, the flexure and impact loads show a consistent difference in failure behaviour of these two systems, owing to the role of out-of-plane-loading in QI ply. Classical lamination theory (CLT) and the numerical methods were employed to conduct stress analysis. Experimental results are discussed in comparison with the finite element method (FEM) and the analytical results. Two types of impactors were employed for the impact tests. One is of a hemispherical-end and other is of a conical-end. Coupon level specimens were supported on all four sides during the impact test. The impact energy was calculated for the laminates and the difference, as a comparison, in each case is presented. It has been observed that the layup sequence has a significant effect on the impact resistance of the laminates under hemispherical impactor. In the case of conical impactor, both the laminates were perforated while absorbing similar energy levels.