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Pd(II) directed self-assembled multi-cavity coordination cages

Pd(II) directed self-assembled multi-cavity coordination cages

தேதி22nd Nov 2022

Time04:00 PM

Venue offline - CB310, Seminar Hall, Department of Chemistry.

PAST EVENT

Details

Abstract: Complexation of suitable non-chelating bidentate ligands with naked Pd(II) is known to provide PdnL2n-type mono-cavity cages (n = 2 to 7, 12, 24, 30 and 48).[1] Smaller cavities of cage molecules can bind small sized guests whereas bigger cavities can accommodate larger guest molecules of compatible size or multiple number of smaller guest molecules. Such host-guest systems are explored in studies like catalysis, molecular transport and allosteric regulation.[3] While increasing the cavity size of a cage is interesting, increasing the number of cavities in a cage i.e making of multi-cavity cages has been gaining interest in recent time.[2] Multi-cavity cages are capable of selective binding of one or more type of guests in segregated manner,[3] including allosteric binding of selected guests due to cooperativity in the host.[4] Multi-cavity cages having as many as four cavities are known in literature.[5] A multi-cavity cage can be prepared by complexation of Pd(II) with one or more types of appropriately designed non-chelating polydentate ligands (a representative double-cavity cage is shown in Fig (i)).[2],[4],[5] We propose to prepare double-cavity cages by introducing a new approach of post-assembly cage modification, where a single cavity is divided into smaller cavities by adding a partition, as shown in Fig (ii). Keeping in mind the above two approaches we have designed a few ligands to prepare double- and triple-cavity cages. Synthesis of some of the designer ligands is under progress. Further objectives of the work are the study of heterotopic guest binding and cooperative guest binding using the new cages. A few mono-cavity cages prepared using certain bidentate ligands will be discussed in the seminar.[6],[7] These bidentate ligands are taken as basis for the designing of multidentae ligands aiming at synthesis of multicavity cages.
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[1] Saha, S.; Regeni, I.; Clever, G. H. Coord. Chem. Rev. 2018, 374, 1.
[2] Vasdev, R. A. S.; Preston, D.; Crowley, J. D. Chem. Asian J. 2017, 12, 2513.
[3] Rizzuto, F. J.; von Krbek, L. K. S.; Nitschke, J. R. Nat. Rev. 2019, 3, 204.
[4] Bandi, S.; Chand, D. K. Chem. Eur. J. 2014, 20, 1–6
[5] Samantray, S.; Chand, D. K. Nat. Commun. 2020, 11, Art. No. 880
[6] Devan et. al. Unpublished work
[7] Gupta et. al. Unpublished work

Speakers

Ms. Kriti Gupta (CY20D013)

Department of Chemistry