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Palladium-Catalyzed Dual C-H Activation Reactions

Palladium-Catalyzed Dual C-H Activation Reactions

தேதி14th Nov 2022

Time11:30 AM

Venue offline - CB310, Seminar Hall, Department of Chemistry.

PAST EVENT

Details

Over the past few decades, transition metal-catalyzed synthetic transformations have gained profound importance as it proves to be a powerful strategy to enable C–C and C–heteroatom bond formation in a highly atom- and step-economical manner. In recent years, transition-metal-catalyzed C−H bond activation has come out as a most straightforward and powerful tool. The success of transition-metal-catalyzed C–H activation for the formation of new C-C bonds has anticipated synthetic chemists to develop double C–H activation protocol. This protocol enables the formation of multiple bonds in one pot, making it more atom- and step-economical compared to available methods. In the literature, oxidative coupling via dual C-H activation for arylation is well explored.[1] However, use of pi-components such as alkynes, alkenes as a coupling partner using this protocol are still unexplored. Recently, oxidative coupling between arene and olefines via 2-fold C-H activation evolving as an important and fascinating research topic to build a cyclic complex organic moiety effortlessly.[2]
In this research proposal seminar, the literature background of palladium-catalyzed dual CH activation followed by functionalization will be discussed along with future perspective on the Pd-catalyzed [3+2] annulation with alkenes through dual CH activation.[3]

References
1. S.-L. You, J.-B. Xia, Top. Curr. Chem. 2010 292, 165; J. Liu, X. Xiong, J. Chen, Y. Wang, R. Zhu, J. Huang Curr. Org. Synth., 2018, 15, 882.
2. Y. Minami, T. Hiyama, Tetrahedron Lett., 2018, 59, 781; Z. Shi, S. Ding, Y. Cui, N. Jiao, Angew. Chem. Int. Ed. 2009, 48, 7895.
3. G. Naskar, M. Jeganmohan, Chem. Eur. J. 2022, e202200778.

Speakers

Mr. Gouranga Naskar (CY18D125)

Department of Chemistry