Number of complexes	183
Number of PDB structures	189
Number of literature sources	223
Single mutation entries	5160
Double mutation entries	776
Entries with 3 or more mutations	544
Entries containing Ala mutations	4337
Entries containing Non-Ala mutations	2143
Total number of entries	6480

Entries by Functional Class

Ag-Ab	2320
EI	2118
GC	104
HR	373
Misc	71
OE	330
RC	453
Unassigned	711

Parameter	Minimum value	Maximum value
Wild-type KD (M)	3.30e-16	1.50e-03
Mutant KD (M)	2.00e-16	4.05e-02
Wild-type kon (1/Ms)	3.10e-03	7.00e+08
Mutant kon (1/Ms)	2.30e-03	6.10e+09
Wild-type koff (1/s)	5.00e-08	1.60e+03
Mutant koff (1/s)	2.30e-09	8.40e+05
ΔΔG (kcal/mol)	-12.22	14.0

The first column represents wild-type residues. The first row represents mutated residues.
For example, to find the number of C to S mutants, locate the C-row, and then the value in the S-column.

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	0	4	32	9	15	46	7	10	15	15	13	9	12	9	40	18	23	94	4	8
C	27	0	0	0	6	0	0	0	0	6	0	0	0	0	0	10	0	0	0	0
D	441	0	0	36	8	16	11	5	41	9	0	38	2	2	11	11	5	0	11	6
E	468	9	346	0	8	29	18	6	44	11	12	7	9	37	18	14	5	5	17	9
F	313	3	1	0	0	1	0	1	1	8	2	1	4	0	1	3	0	5	7	8
G	82	4	41	8	5	0	10	8	9	8	11	19	8	4	5	108	16	15	4	6
H	138	0	16	2	3	4	0	0	9	1	0	20	5	15	20	0	0	0	0	13
I	176	0	0	2	2	0	0	0	4	2	9	2	0	0	7	0	3	4	1	0
K	420	16	28	45	13	18	6	20	0	6	21	9	5	35	53	8	33	27	6	6
L	364	10	12	12	30	11	35	46	25	0	99	7	27	22	50	15	9	36	14	10
M	74	0	1	1	3	4	1	4	10	12	0	0	0	2	4	0	4	1	1	4
N	265	5	58	10	7	7	10	9	27	13	4	0	5	10	12	126	4	19	6	8
P	141	4	4	5	6	5	4	4	8	4	4	4	0	4	4	19	5	4	4	4
Q	225	0	4	17	0	0	3	1	8	43	0	0	0	0	3	0	0	3	0	0
R	489	6	9	28	13	9	7	4	27	12	151	15	8	25	0	5	16	19	8	6
S	398	1	10	15	1	9	0	0	8	1	12	27	6	2	9	0	29	3	0	10
T	244	8	18	19	38	9	4	25	46	28	11	19	36	6	20	104	0	20	5	6
V	230	0	1	2	5	2	0	20	6	3	6	2	0	0	0	23	13	0	0	2
W	130	0	1	0	24	0	0	0	1	1	0	0	1	0	5	0	0	0	0	5
Y	411	6	28	9	87	28	23	5	6	16	5	8	5	18	8	21	5	6	17	0

This link will provide an Excel file which contains information on how many entries are mapped to the protein-protein complexes and references. The file is available here. Note:Please download this file using a recent version of Firefox or Chrome. For more information, please see our FAQs.