Overview

MPTherm is a thermodynamic database of membrane proteins and their mutants, contains the thermodynamic data of membrane proteins collected from literature and ProThermDB database. Currently, we have data for around 7,000 mutations in more than 300 membrane proteins with several sequence-, structure-based features and membrane topology information. In addition, for each data we provide the exact location of data in the literature and these data cross linked with UniProt and PDB databases.

MPTherm can be queried through the search options by giving UniProt ID, PDB ID, gene name, mutation, topology, experimental conditions, author name and journal name, etc. Users can check our tutorial to get help in searching the database. Fill the download form provided to download the entire dataset.

Please cite us if the use of this database has helped you in your work and or resulted in any publication: A. Kulandaisamy, R. Sakthivel and M. Michael Gromiha* (2020) MPTherm: Database for Membrane Protein Thermodynamics for understanding folding and stability. Brief Bioinform, (2020) bbaa064.