MPTherm

Statistics

✪ Summary of MPTherm

Mutation type	Number of mutations
Wild-type	3, 808
Single	2, 330
Double	362
Multiple	681
Deletions	8

✪ Distribution of single point mutations in different topological regions

Topological region	Number of mutations
Cytoplasm or Inside	674
Membrane	1, 161
Extra-cellular or Outside	480
Others	15

✪ Distribution of data in different transmembrane (TM) segments

Number of transmembrane segments	Number of data (Wild-type)	Number of data (Single point mutations)
1	789	272
2	587	88
3	41	115
4	102	44
5	88	-
6	293	386
7	781	477
8	153	354
9	26	36
10	121	6
11	24	6
12	423	403
13	25	28
14	210	33
16	11	46
17	84	6
19	1	-
20	3	3
22	12	16
24	7	7
25	7	4

✪ Mutation frequency for the whole dataset point mutations of MPTherm database

The columns represent wild-type residues. The rows represent mutated residues. For example, to find the number of A to V mutants, locate the A-row, and then the value in the V-column.

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		11	3	1	11	10	14	5	3	37	3	3	14	1	3	6	2	18	3	2
C	36		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	54	2		14	0	11	0	0	6	0	0	44	0	0	8	1	1	0	0	2
E	66	3	3		0	2	6	0	10	19	3	24	0	29	2	0	0	0	0	0
F	47	9	4	1		3	2	0	1	10	1	8	1	2	1	3	0	3	27	7
G	50	3	11	2	0		0	1	0	11	8	0	1	0	14	4	0	22	2	0
H	51	1	1	0	19	0		0	1	7	0	4	0	5	3	6	0	0	0	0
I	43	3	1	0	3	1	0		0	19	9	2	1	0	0	1	4	14	3	1
K	68	1	0	14	0	1	7	0		2	1	25	2	4	6	3	4	0	1	0
L	73	12	2	0	13	4	6	2	0		1	3	4	3	4	8	0	14	13	1
M	21	7	5	0	1	0	0	1	2	1		0	1	1	1	0	2	2	0	0
N	55	4	4	1	0	0	0	3	0	0	2		6	3	4	1	2	0	1	0
P	22	2	0	0	0	1	0	0	0	2	0	0		0	4	3	0	1	0	0
Q	35	2	2	5	1	1	1	5	8	10	1	1	1		3	1	1	1	1	1
R	60	10	1	6	0	4	6	0	4	8	5	24	1	7		8	0	0	5	1
S	75	4	1	3	4	1	1	1	3	6	1	2	4	0	3		3	0	0	0
T	48	3	3	2	1	1	0	9	1	4	4	4	9	2	6	4		1	0	0
V	42	7	6	7	26	1	7	12	4	16	5	1	2	1	5	2	2		1	6
W	40	7	0	0	89	1	1	0	0	2	0	0	1	0	2	0	0	0		19
Y	46	8	0	0	33	1	1	0	0	3	0	0	2	0	1	2	0	0	5

✪ Mutation frequency for a set of non-redundant point mutations (sequence identity <30%)

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		8	3	1	11	8	14	5	3	36	2	3	9	1	3	6	2	17	3	2
C	31		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	53	2		13	0	11	0	0	6	0	0	12	0	0	4	1	1	0	0	2
E	59	3	2		0	1	6	0	6	3	0	0	0	29	2	0	0	0	0	0
F	37	4	4	1		2	0	0	1	7	1	8	1	2	1	3	0	3	27	4
G	47	2	11	2	0		0	1	0	11	8	0	1	0	11	4	0	22	2	0
H	44	0	0	0	12	0		0	1	5	0	1	0	5	3	6	0	0	0	0
I	43	2	1	0	2	0	0		0	18	9	2	0	0	0	1	4	13	2	0
K	68	0	0	10	0	1	7	0		2	1	3	2	3	5	3	4	0	1	0
L	71	11	2	0	13	4	6	1	0		1	3	2	1	4	8	0	14	13	1
M	16	5	3	0	1	0	0	1	2	1		0	0	1	1	0	2	2	0	0
N	48	4	4	1	0	0	0	3	0	0	2		1	3	4	0	1	0	1	0
P	14	0	0	0	0	1	0	0	0	2	0	0		0	1	1	0	1	0	0
Q	28	1	1	2	0	0	0	4	7	8	0	0	0		2	0	0	0	0	0
R	59	9	1	6	0	4	6	0	3	8	1	0	0	3		7	0	0	5	1
S	73	4	1	3	4	1	1	1	1	4	1	0	4	0	3		3	0	0	0
T	45	3	3	2	1	1	0	9	1	3	3	0	4	2	6	4		1	0	0
V	41	5	5	1	25	0	1	9	1	14	3	0	0	0	4	1	1		0	0
W	38	3	0	0	81	1	1	0	0	2	0	0	0	0	2	0	0	0		17
Y	40	3	0	0	27	1	0	0	0	3	0	0	1	0	1	2	0	0	5

Number of transmembrane segments	Number of data (Wild-type)	Number of data (Single point mutations)
1	789	272
2	587	88
3	41	115
4	102	44
5	88	-
6	293	386
7	781	477
8	153	354
9	26	36
10	121	6
11	24	6
12	423	403
13	25	28
14	210	33
16	11	46
17	84	6
19	1	-
20	3	3
22	12	16
24	7	7
25	7	4

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		11	3	1	11	10	14	5	3	37	3	3	14	1	3	6	2	18	3	2
C	36		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	54	2		14	0	11	0	0	6	0	0	44	0	0	8	1	1	0	0	2
E	66	3	3		0	2	6	0	10	19	3	24	0	29	2	0	0	0	0	0
F	47	9	4	1		3	2	0	1	10	1	8	1	2	1	3	0	3	27	7
G	50	3	11	2	0		0	1	0	11	8	0	1	0	14	4	0	22	2	0
H	51	1	1	0	19	0		0	1	7	0	4	0	5	3	6	0	0	0	0
I	43	3	1	0	3	1	0		0	19	9	2	1	0	0	1	4	14	3	1
K	68	1	0	14	0	1	7	0		2	1	25	2	4	6	3	4	0	1	0
L	73	12	2	0	13	4	6	2	0		1	3	4	3	4	8	0	14	13	1
M	21	7	5	0	1	0	0	1	2	1		0	1	1	1	0	2	2	0	0
N	55	4	4	1	0	0	0	3	0	0	2		6	3	4	1	2	0	1	0
P	22	2	0	0	0	1	0	0	0	2	0	0		0	4	3	0	1	0	0
Q	35	2	2	5	1	1	1	5	8	10	1	1	1		3	1	1	1	1	1
R	60	10	1	6	0	4	6	0	4	8	5	24	1	7		8	0	0	5	1
S	75	4	1	3	4	1	1	1	3	6	1	2	4	0	3		3	0	0	0
T	48	3	3	2	1	1	0	9	1	4	4	4	9	2	6	4		1	0	0
V	42	7	6	7	26	1	7	12	4	16	5	1	2	1	5	2	2		1	6
W	40	7	0	0	89	1	1	0	0	2	0	0	1	0	2	0	0	0		19
Y	46	8	0	0	33	1	1	0	0	3	0	0	2	0	1	2	0	0	5

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		8	3	1	11	8	14	5	3	36	2	3	9	1	3	6	2	17	3	2
C	31		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	53	2		13	0	11	0	0	6	0	0	12	0	0	4	1	1	0	0	2
E	59	3	2		0	1	6	0	6	3	0	0	0	29	2	0	0	0	0	0
F	37	4	4	1		2	0	0	1	7	1	8	1	2	1	3	0	3	27	4
G	47	2	11	2	0		0	1	0	11	8	0	1	0	11	4	0	22	2	0
H	44	0	0	0	12	0		0	1	5	0	1	0	5	3	6	0	0	0	0
I	43	2	1	0	2	0	0		0	18	9	2	0	0	0	1	4	13	2	0
K	68	0	0	10	0	1	7	0		2	1	3	2	3	5	3	4	0	1	0
L	71	11	2	0	13	4	6	1	0		1	3	2	1	4	8	0	14	13	1
M	16	5	3	0	1	0	0	1	2	1		0	0	1	1	0	2	2	0	0
N	48	4	4	1	0	0	0	3	0	0	2		1	3	4	0	1	0	1	0
P	14	0	0	0	0	1	0	0	0	2	0	0		0	1	1	0	1	0	0
Q	28	1	1	2	0	0	0	4	7	8	0	0	0		2	0	0	0	0	0
R	59	9	1	6	0	4	6	0	3	8	1	0	0	3		7	0	0	5	1
S	73	4	1	3	4	1	1	1	1	4	1	0	4	0	3		3	0	0	0
T	45	3	3	2	1	1	0	9	1	3	3	0	4	2	6	4		1	0	0
V	41	5	5	1	25	0	1	9	1	14	3	0	0	0	4	1	1		0	0
W	38	3	0	0	81	1	1	0	0	2	0	0	0	0	2	0	0	0		17
Y	40	3	0	0	27	1	0	0	0	3	0	0	1	0	1	2	0	0	5

Number of transmembrane segments	Number of data (Wild-type)	Number of data (Single point mutations)
1	789	272
2	587	88
3	41	115
4	102	44
5	88	-
6	293	386
7	781	477
8	153	354
9	26	36
10	121	6
11	24	6
12	423	403
13	25	28
14	210	33
16	11	46
17	84	6
19	1	-
20	3	3
22	12	16
24	7	7
25	7	4

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		11	3	1	11	10	14	5	3	37	3	3	14	1	3	6	2	18	3	2
C	36		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	54	2		14	0	11	0	0	6	0	0	44	0	0	8	1	1	0	0	2
E	66	3	3		0	2	6	0	10	19	3	24	0	29	2	0	0	0	0	0
F	47	9	4	1		3	2	0	1	10	1	8	1	2	1	3	0	3	27	7
G	50	3	11	2	0		0	1	0	11	8	0	1	0	14	4	0	22	2	0
H	51	1	1	0	19	0		0	1	7	0	4	0	5	3	6	0	0	0	0
I	43	3	1	0	3	1	0		0	19	9	2	1	0	0	1	4	14	3	1
K	68	1	0	14	0	1	7	0		2	1	25	2	4	6	3	4	0	1	0
L	73	12	2	0	13	4	6	2	0		1	3	4	3	4	8	0	14	13	1
M	21	7	5	0	1	0	0	1	2	1		0	1	1	1	0	2	2	0	0
N	55	4	4	1	0	0	0	3	0	0	2		6	3	4	1	2	0	1	0
P	22	2	0	0	0	1	0	0	0	2	0	0		0	4	3	0	1	0	0
Q	35	2	2	5	1	1	1	5	8	10	1	1	1		3	1	1	1	1	1
R	60	10	1	6	0	4	6	0	4	8	5	24	1	7		8	0	0	5	1
S	75	4	1	3	4	1	1	1	3	6	1	2	4	0	3		3	0	0	0
T	48	3	3	2	1	1	0	9	1	4	4	4	9	2	6	4		1	0	0
V	42	7	6	7	26	1	7	12	4	16	5	1	2	1	5	2	2		1	6
W	40	7	0	0	89	1	1	0	0	2	0	0	1	0	2	0	0	0		19
Y	46	8	0	0	33	1	1	0	0	3	0	0	2	0	1	2	0	0	5

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		8	3	1	11	8	14	5	3	36	2	3	9	1	3	6	2	17	3	2
C	31		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	53	2		13	0	11	0	0	6	0	0	12	0	0	4	1	1	0	0	2
E	59	3	2		0	1	6	0	6	3	0	0	0	29	2	0	0	0	0	0
F	37	4	4	1		2	0	0	1	7	1	8	1	2	1	3	0	3	27	4
G	47	2	11	2	0		0	1	0	11	8	0	1	0	11	4	0	22	2	0
H	44	0	0	0	12	0		0	1	5	0	1	0	5	3	6	0	0	0	0
I	43	2	1	0	2	0	0		0	18	9	2	0	0	0	1	4	13	2	0
K	68	0	0	10	0	1	7	0		2	1	3	2	3	5	3	4	0	1	0
L	71	11	2	0	13	4	6	1	0		1	3	2	1	4	8	0	14	13	1
M	16	5	3	0	1	0	0	1	2	1		0	0	1	1	0	2	2	0	0
N	48	4	4	1	0	0	0	3	0	0	2		1	3	4	0	1	0	1	0
P	14	0	0	0	0	1	0	0	0	2	0	0		0	1	1	0	1	0	0
Q	28	1	1	2	0	0	0	4	7	8	0	0	0		2	0	0	0	0	0
R	59	9	1	6	0	4	6	0	3	8	1	0	0	3		7	0	0	5	1
S	73	4	1	3	4	1	1	1	1	4	1	0	4	0	3		3	0	0	0
T	45	3	3	2	1	1	0	9	1	3	3	0	4	2	6	4		1	0	0
V	41	5	5	1	25	0	1	9	1	14	3	0	0	0	4	1	1		0	0
W	38	3	0	0	81	1	1	0	0	2	0	0	0	0	2	0	0	0		17
Y	40	3	0	0	27	1	0	0	0	3	0	0	1	0	1	2	0	0	5

Number of transmembrane segments	Number of data (Wild-type)	Number of data (Single point mutations)
1	789	272
2	587	88
3	41	115
4	102	44
5	88	-
6	293	386
7	781	477
8	153	354
9	26	36
10	121	6
11	24	6
12	423	403
13	25	28
14	210	33
16	11	46
17	84	6
19	1	-
20	3	3
22	12	16
24	7	7
25	7	4

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		11	3	1	11	10	14	5	3	37	3	3	14	1	3	6	2	18	3	2
C	36		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	54	2		14	0	11	0	0	6	0	0	44	0	0	8	1	1	0	0	2
E	66	3	3		0	2	6	0	10	19	3	24	0	29	2	0	0	0	0	0
F	47	9	4	1		3	2	0	1	10	1	8	1	2	1	3	0	3	27	7
G	50	3	11	2	0		0	1	0	11	8	0	1	0	14	4	0	22	2	0
H	51	1	1	0	19	0		0	1	7	0	4	0	5	3	6	0	0	0	0
I	43	3	1	0	3	1	0		0	19	9	2	1	0	0	1	4	14	3	1
K	68	1	0	14	0	1	7	0		2	1	25	2	4	6	3	4	0	1	0
L	73	12	2	0	13	4	6	2	0		1	3	4	3	4	8	0	14	13	1
M	21	7	5	0	1	0	0	1	2	1		0	1	1	1	0	2	2	0	0
N	55	4	4	1	0	0	0	3	0	0	2		6	3	4	1	2	0	1	0
P	22	2	0	0	0	1	0	0	0	2	0	0		0	4	3	0	1	0	0
Q	35	2	2	5	1	1	1	5	8	10	1	1	1		3	1	1	1	1	1
R	60	10	1	6	0	4	6	0	4	8	5	24	1	7		8	0	0	5	1
S	75	4	1	3	4	1	1	1	3	6	1	2	4	0	3		3	0	0	0
T	48	3	3	2	1	1	0	9	1	4	4	4	9	2	6	4		1	0	0
V	42	7	6	7	26	1	7	12	4	16	5	1	2	1	5	2	2		1	6
W	40	7	0	0	89	1	1	0	0	2	0	0	1	0	2	0	0	0		19
Y	46	8	0	0	33	1	1	0	0	3	0	0	2	0	1	2	0	0	5

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A		8	3	1	11	8	14	5	3	36	2	3	9	1	3	6	2	17	3	2
C	31		0	0	1	4	0	0	0	6	1	7	0	1	4	13	1	2	1	1
D	53	2		13	0	11	0	0	6	0	0	12	0	0	4	1	1	0	0	2
E	59	3	2		0	1	6	0	6	3	0	0	0	29	2	0	0	0	0	0
F	37	4	4	1		2	0	0	1	7	1	8	1	2	1	3	0	3	27	4
G	47	2	11	2	0		0	1	0	11	8	0	1	0	11	4	0	22	2	0
H	44	0	0	0	12	0		0	1	5	0	1	0	5	3	6	0	0	0	0
I	43	2	1	0	2	0	0		0	18	9	2	0	0	0	1	4	13	2	0
K	68	0	0	10	0	1	7	0		2	1	3	2	3	5	3	4	0	1	0
L	71	11	2	0	13	4	6	1	0		1	3	2	1	4	8	0	14	13	1
M	16	5	3	0	1	0	0	1	2	1		0	0	1	1	0	2	2	0	0
N	48	4	4	1	0	0	0	3	0	0	2		1	3	4	0	1	0	1	0
P	14	0	0	0	0	1	0	0	0	2	0	0		0	1	1	0	1	0	0
Q	28	1	1	2	0	0	0	4	7	8	0	0	0		2	0	0	0	0	0
R	59	9	1	6	0	4	6	0	3	8	1	0	0	3		7	0	0	5	1
S	73	4	1	3	4	1	1	1	1	4	1	0	4	0	3		3	0	0	0
T	45	3	3	2	1	1	0	9	1	3	3	0	4	2	6	4		1	0	0
V	41	5	5	1	25	0	1	9	1	14	3	0	0	0	4	1	1		0	0
W	38	3	0	0	81	1	1	0	0	2	0	0	0	0	2	0	0	0		17
Y	40	3	0	0	27	1	0	0	0	3	0	0	1	0	1	2	0	0	5