Mutations are permanent changes in the DNA sequences that may affect the proper functioning of a protein thereby lead to a disease. Effective healthcare to the affected persons mainly depends on studying the variants resulted from these mutations. Human genetic variants are being reported worldwide and are collected in different databases. We present here the HuVarBase, a comprehensive database on human variants reported in the databases namely Humsavar, 1000 Genomes, SwissVar, ClinVar and COSMIC.
The database has 774,863 variants from 18,318 proteins. Among the variants 702,048 are disease causing and 72,815 are neutral variants. The database can be searched by giving keywords like Gene name, PDB ID, UniProt ID, Protein function, Subcellular localization, Post-translational modifications etc. You can search the database here
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