CITATION AND ACKNOWLEDGEMENT
Please cite us if the use of this prediction server has helped you in your work and /or resulted in any publication:
Jemimah S, and Gromiha MM. Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes.
Proteins. In press.
We are grateful for the use of the JSmol applet to view the complex structure with the mutations in the Prediction Results page. Thanks to the developers of scikit-learn for the use of their modules for machine learning. We also acknowledge Bio.PDB's DSSP module from Biopython for DSSP calculations using DSSP 2.0.4., and PDBparam for calculation of surrounding hydrophobicity and long range order.
- DSSP: Kabsch W, Sander C. Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers 1983; 22(12):2577-2637.
- Scikit-learn: Pedregosa F et al. Scikit-learn: Machine Learning in Python. J Mach Learn Res 2011; 12(Oct): 2825-2830.
- JSmol: Hanson RM et al. JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Israel J Chem 2013; 53:207-216.
- PDBparam: Nagarajan R et al. PDBparam: Online Resource for Computing Structural Parameters of Proteins. Bioinform Biol Insights 2016; 10:73-80.