Sequence Based Features Extraction

Compressibility

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-25.5	-33.12	-32.82	-36.17	-34.54	-27	-31.84	-31.78	-32.4	-31.78	-31.18	-30.9	-23.25	-32.6	-26.62	-29.88	-31.23	-30.62	-30.24	-35.01
Normalized value	0.83	0.24	0.26	0	0.13	0.71	0.34	0.34	0.29	0.34	0.39	0.41	1	0.28	0.74	0.49	0.38	0.43	0.46	0.09

Thermodynamic transfer hydrophobicity

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.87	0.66	1.52	0.67	2.87	0.1	0.87	3.15	1.64	2.17	1.67	0.09	2.77	0	0.85	0.07	0.07	1.87	3.77	2.67
Normalized value	0.23	0.18	0.4	0.18	0.76	0.03	0.23	0.84	0.44	0.58	0.44	0.02	0.73	0	0.23	0.02	0.02	0.5	1	0.71

Surrounding hydrophobicity

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	13.05	11.1	14.3	11.41	13.89	12.2	12.42	15.34	11.01	14.19	13.62	11.72	11.06	11.78	12.4	11.68	12.12	14.73	13.96	13.57
Normalized value	0.47	0.02	0.76	0.09	0.67	0.27	0.33	1	0	0.73	0.6	0.16	0.01	0.18	0.32	0.15	0.26	0.86	0.68	0.59

Polarity

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0	49.7	1.48	49.9	0.35	0	51.6	0.1	49.5	0.13	1.43	3.38	1.58	3.53	52	1.67	1.66	0.13	2.1	1.61
Normalized value	0	0.96	0.03	0.96	0.01	0	0.99	0	0.95	0	0.03	0.07	0.03	0.07	1	0.03	0.03	0	0.04	0.03

pHi

Isoelectric point

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	6	2.77	5.05	5.22	5.48	5.97	7.59	6.02	9.74	5.98	5.74	5.41	6.3	5.65	10.76	5.68	5.66	5.96	5.89	5.66
Normalized value	0.4	0	0.29	0.31	0.34	0.4	0.6	0.41	0.87	0.4	0.37	0.33	0.44	0.36	1	0.36	0.36	0.4	0.39	0.36

pK'

Equilibrium constant with reference to the ionization property of COOH group

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	2.34	2.01	1.65	2.19	1.89	2.34	1.82	1.36	2.18	2.36	2.28	2.02	1.99	2.17	1.81	2.21	2.1	2.32	2.38	2.2
Normalized value	0.96	0.64	0.28	0.81	0.52	0.96	0.45	0	0.8	0.98	0.9	0.65	0.62	0.79	0.44	0.83	0.73	0.94	1	0.82

Molecular weight

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	89	133	121	147	165	75	155	131	146	131	149	132	115	146	174	105	119	117	204	181
Normalized value	0.11	0.45	0.36	0.56	0.7	0	0.62	0.43	0.55	0.43	0.57	0.44	0.31	0.55	0.77	0.23	0.34	0.33	1	0.82

Bulkiness

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	11.5	11.68	13.46	13.57	19.8	3.4	13.67	21.4	15.71	21.4	16.25	12.82	17.43	14.45	14.28	9.47	15.77	21.57	21.61	18.03
Normalized value	0.44	0.45	0.55	0.56	0.9	0	0.56	0.99	0.68	0.99	0.71	0.52	0.77	0.61	0.6	0.33	0.68	1	1	0.8

Chromatographic index

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	9.9	2.8	2.8	3.2	18.8	5.6	8.2	17.1	3.5	17.6	14.7	5.4	14.8	9	4.6	6.9	9.5	14.3	17	15
Normalized value	0.44	0	0	0.03	1	0.18	0.34	0.89	0.04	0.93	0.74	0.16	0.75	0.39	0.11	0.26	0.42	0.72	0.89	0.76

Refractive index

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	14.34	12	35.77	17.26	29.4	0	21.81	19.06	21.29	18.78	21.64	13.28	10.93	17.56	26.66	6.35	11.01	13.92	42.53	31.55
Normalized value	0.34	0.28	0.84	0.41	0.69	0	0.51	0.45	0.5	0.44	0.51	0.31	0.26	0.41	0.63	0.15	0.26	0.33	1	0.74

Hnc

Normalized consensus hydrophobicity

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.62	0.9	0.29	-0.74	1.19	0.48	-0.4	1.38	-1.5	1.06	0.64	-0.78	0.12	-0.85	-2.53	-0.18	-0.05	1.08	0.81	0.26
Normalized value	0.81	0.88	0.72	0.46	0.95	0.77	0.54	1	0.26	0.92	0.81	0.45	0.68	0.43	0	0.6	0.63	0.92	0.85	0.71

Esm

Short and medium range non-bonded energy

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.4	1.16	1.37	1.16	1.14	1.36	1.22	1.19	1.07	1.32	1.3	1.18	1.24	1.12	0.92	1.3	1.25	1.25	1.03	1.03
Normalized value	1	0.5	0.94	0.5	0.46	0.92	0.63	0.56	0.31	0.83	0.79	0.54	0.67	0.42	0	0.79	0.69	0.69	0.23	0.23

Long-rangenon-bondedenergy

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.49	0.35	0.67	0.37	0.72	0.53	0.54	0.76	0.3	0.65	0.65	0.38	0.46	0.4	0.55	0.45	0.52	0.73	0.83	0.65
Normalized value	0.36	0.09	0.7	0.13	0.79	0.43	0.45	0.87	0	0.66	0.66	0.15	0.3	0.19	0.47	0.28	0.42	0.81	1	0.66

Total non-bonded energy

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.9	1.52	2.04	1.54	1.86	1.9	1.76	1.95	1.37	1.97	1.96	1.56	1.7	1.52	1.48	1.75	1.77	1.98	1.87	1.69
Normalized value	0.79	0.22	1	0.25	0.73	0.79	0.58	0.87	0	0.9	0.88	0.28	0.49	0.22	0.16	0.57	0.6	0.91	0.75	0.48

Alpha-helical tendency

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.42	1.01	0.7	1.51	1.13	0.57	1	1.08	1.16	1.21	1.45	0.67	0.57	1.11	0.98	0.77	0.83	1.06	1.08	0.69
Normalized value	0.9	0.47	0.14	1	0.6	0	0.46	0.54	0.63	0.68	0.94	0.11	0	0.57	0.44	0.21	0.28	0.52	0.54	0.13

Beta-helical tendency

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.83	0.54	1.19	0.37	1.38	0.75	0.87	1.6	0.74	1.3	1.05	0.89	0.55	1.1	0.93	0.75	1.19	1.7	1.37	1.47
Normalized value	0.35	0.13	0.62	0	0.76	0.29	0.38	0.92	0.28	0.7	0.51	0.39	0.14	0.55	0.42	0.29	0.62	1	0.75	0.83

Turn tendency

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.66	1.46	1.19	0.74	0.6	1.56	0.95	0.47	1.01	0.59	0.6	1.56	1.52	0.98	0.95	1.43	0.96	0.5	0.96	1.14
Normalized value	0.17	0.91	0.66	0.25	0.12	1	0.44	0	0.5	0.11	0.12	1	0.96	0.47	0.44	0.88	0.45	0.03	0.45	0.61

Coil tendency

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.71	1.21	1.19	0.84	0.71	1.52	1.07	0.66	0.99	0.69	0.59	1.37	1.61	0.87	1.07	1.34	1.08	0.63	0.76	1.07
Normalized value	0.12	0.61	0.59	0.25	0.12	0.91	0.47	0.07	0.39	0.1	0	0.76	1	0.27	0.47	0.74	0.48	0.04	0.17	0.47

Helical contact area

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	20	26	25	33	46	13	37	39	46	35	43	28	22	36	55	20	28	33	61	46
Normalized value	0.15	0.27	0.25	0.42	0.69	0	0.5	0.54	0.69	0.46	0.62	0.31	0.19	0.48	0.88	0.15	0.31	0.42	1	0.69

Mean rms fluctuation al displacement

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.96	1.14	0.87	1.07	0.69	1.16	0.8	0.76	1.14	0.79	0.78	1.04	1.16	1.07	1.05	1.13	0.96	0.79	0.77	1.01
Normalized value	0.57	0.96	0.38	0.81	0	1	0.23	0.15	0.96	0.21	0.19	0.74	1	0.81	0.77	0.94	0.57	0.21	0.17	0.68

Buriedness

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.38	0.14	0.57	0.09	0.51	0.38	0.31	0.56	0.04	0.5	0.42	0.15	0.18	0.11	0.07	0.23	0.23	0.48	0.4	0.26
Normalized value	0.64	0.19	1	0.09	0.89	0.64	0.51	0.98	0	0.87	0.72	0.21	0.26	0.13	0.06	0.36	0.36	0.83	0.68	0.42

Solvent accessible reduction ratio

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	3.7	2.6	3.03	3.3	6.6	3.13	3.57	7.69	1.79	5.88	5.21	2.12	2.12	2.7	2.53	2.43	2.6	7.14	6.25	3.03
Normalized value	0.32	0.14	0.21	0.26	0.82	0.23	0.3	1	0	0.69	0.58	0.06	0.06	0.15	0.13	0.11	0.14	0.91	0.76	0.21

Average number of surrounding residues

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	6.05	4.95	7.86	5.1	6.62	6.16	5.8	7.51	4.88	7.37	6.39	5.04	5.65	5.45	5.7	5.53	5.81	7.62	6.98	6.73
Normalized value	0.39	0.02	1	0.07	0.58	0.43	0.31	0.88	0	0.84	0.51	0.05	0.26	0.19	0.28	0.22	0.31	0.92	0.7	0.62

Power to beat the N-terminal of alphahelix

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.59	0.53	0.33	1.45	1.14	0.53	0.89	1.22	1.13	1.91	1.25	0.53	0	0.98	0.67	0.7	0.75	1.42	1.33	0.58
Normalized value	0.83	0.28	0.17	0.76	0.6	0.28	0.47	0.64	0.59	1	0.65	0.28	0	0.51	0.35	0.37	0.39	0.74	0.7	0.3

Power to beat the C-terminal of alphahelix

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.44	2.13	0.76	2.01	1.01	0.62	0.56	0.68	0.59	0.58	0.73	0.93	2.19	1.2	0.39	0.81	1.25	0.63	1.4	0.72
Normalized value	0.58	0.97	0.21	0.9	0.34	0.13	0.09	0.16	0.11	0.11	0.19	0.3	1	0.45	0	0.23	0.48	0.13	0.56	0.18

Power to beat the middle of alphahelix

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.22	0.56	1.53	1.28	1.13	0.4	2.23	0.77	1.65	1.05	1.47	0.93	0	1.63	1.59	0.87	0.46	1.2	0.46	0.52
Normalized value	0.55	0.25	0.69	0.57	0.51	0.18	1	0.35	0.74	0.47	0.66	0.42	0	0.73	0.71	0.39	0.21	0.54	0.21	0.23

Partial-specific volume

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	60.46	73.83	67.7	85.88	121.48	43.25	98.79	107.72	108.5	107.75	105.35	78.01	82.83	93.9	127.34	60.62	76.83	90.78	143.91	123.6
Normalized value	0.17	0.3	0.24	0.42	0.78	0	0.55	0.64	0.65	0.64	0.62	0.35	0.39	0.5	0.84	0.17	0.33	0.47	1	0.8

Average medium-range contacts

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	2.11	1.8	1.88	2.09	1.98	1.53	1.98	1.77	1.96	2.19	2.27	1.84	1.32	2.03	1.94	1.57	1.57	1.63	1.9	1.67
Normalized value	0.83	0.51	0.59	0.81	0.69	0.22	0.69	0.47	0.67	0.92	1	0.55	0	0.75	0.65	0.26	0.26	0.33	0.61	0.37

Average long-range contacts

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	3.92	2.85	5.55	2.72	4.53	4.31	3.77	5.58	2.79	4.59	4.14	3.64	3.57	3.06	3.78	3.75	4.09	5.43	4.83	4.93
Normalized value	0.42	0.05	0.99	0	0.63	0.56	0.37	1	0.02	0.65	0.5	0.32	0.3	0.12	0.37	0.36	0.48	0.95	0.74	0.77

Hgm

Combined surrounding hydrophobicity (globularandmembrane)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	13.85	11.61	15.37	11.38	13.93	13.34	13.82	15.28	11.58	14.13	13.86	13.02	12.35	12.61	13.1	13.39	12.7	14.56	15.48	13.88
Normalized value	0.6	0.06	0.97	0	0.62	0.48	0.6	0.95	0.05	0.67	0.6	0.4	0.24	0.3	0.42	0.49	0.32	0.78	1	0.61

ASAD

Solvent accessible surface area for denatured protein

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	104	132.2	132.5	161.9	182	73.4	165.8	171.5	195.2	161.4	189.8	134.9	135.1	164.9	210.2	111.4	130.4	143.9	208.8	196.4
Normalized value	0.22	0.43	0.43	0.65	0.79	0	0.68	0.72	0.89	0.64	0.85	0.45	0.45	0.67	1	0.28	0.42	0.52	0.99	0.9

ASAN

Solvent accessible surface area for native protein

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	33.2	62.4	17.9	81	33.1	29.2	57.7	28.3	107.5	31.1	41.3	60.5	60.7	71.5	94.5	48.7	52	28.1	39.5	50.4
Normalized value	0.17	0.5	0	0.7	0.17	0.13	0.44	0.12	1	0.15	0.26	0.48	0.48	0.6	0.85	0.34	0.38	0.11	0.24	0.36

DASA

Solvent accessible surface area for protein unfolding

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	70.9	69.6	114.3	80.5	148.4	44	107.9	142.7	87.5	129.8	147.9	74	73.5	93.3	116	62.8	78	115.6	167.8	145.9
Normalized value	0.22	0.21	0.57	0.29	0.84	0	0.52	0.8	0.35	0.69	0.84	0.24	0.24	0.4	0.58	0.15	0.27	0.58	1	0.82

DGh

Gibbs free energy change of hydration for unfolding

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.54	-2.97	-1.64	-3.71	-1.06	-0.59	-3.38	0.32	-2.19	0.27	-0.6	-3.55	0.32	-3.92	-5.96	-3.82	-1.97	0.13	-3.8	-5.64
Normalized value	0.86	0.48	0.69	0.36	0.78	0.86	0.41	1	0.6	0.99	0.85	0.38	1	0.32	0	0.34	0.64	0.97	0.34	0.05

GhD

Gibbs free energy change of hydration for denatured protein

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.58	-6.1	-1.91	-7.37	-1.35	-0.82	-5.57	0.4	-5.97	0.35	-0.71	-6.63	0.56	-7.12	-12.78	-6.18	-3.66	0.18	-4.71	-8.45
Normalized value	0.91	0.5	0.81	0.41	0.86	0.9	0.54	0.99	0.51	0.98	0.9	0.46	1	0.42	0	0.49	0.68	0.97	0.6	0.32

GdN

Gibbs free energy change of hydration for native protein

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.06	-3.11	-0.27	-3.62	-0.28	-0.23	-2.18	0.07	-1.7	0.07	-0.1	-3.03	0.23	-3.15	-6.85	-2.36	-1.69	0.04	-0.88	-2.82
Normalized value	0.96	0.53	0.93	0.46	0.93	0.94	0.66	0.98	0.73	0.98	0.95	0.54	1	0.52	0	0.63	0.73	0.97	0.84	0.57

DHh

Unfolding enthalpy change of hydration

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-2.24	-4.54	-3.43	-5.63	-5.11	-1.46	-6.83	-3.84	-5.02	-3.52	-4.16	-5.68	-1.95	-6.23	-10.43	-5.94	-4.39	-3.15	-8.99	-10.67
Normalized value	0.92	0.67	0.79	0.55	0.6	1	0.42	0.74	0.61	0.78	0.71	0.54	0.95	0.48	0.03	0.51	0.68	0.82	0.18	0

-TDSh

Unfolding entropy change of hydration

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.7	1.57	1.79	1.92	4.05	0.87	3.45	4.16	2.83	3.79	3.56	2.13	2.27	2.31	4.47	2.12	2.42	3.28	5.19	5.03
0.19	0.16	0.21	0.24	0.74	0	0.6	0.76	0.45	0.68	0.62	0.29	0.32	0.33	0.83	0.29	0.36	0.56	1	0.96

DCph

Unfolding hydration heat capacity change

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	14.22	2.73	9.41	3.17	39.06	4.88	20.05	41.98	17.68	38.26	31.67	3.91	23.69	3.74	16.66	6.14	16.11	32.58	37.69	30.54
Normalized value	0.29	0	0.17	0.01	0.93	0.05	0.44	1	0.38	0.91	0.74	0.03	0.53	0.03	0.35	0.09	0.34	0.76	0.89	0.71

DGc

Unfolding Gibbs free energy change of chain

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.51	2.89	2.71	3.58	3.22	0.68	3.95	-0.4	1.87	-0.35	1.13	3.26	-0.39	3.69	5.25	3.42	1.74	-0.19	5.59	6.56
Normalized value	0.13	0.47	0.45	0.57	0.52	0.16	0.62	0	0.33	0.01	0.22	0.53	0	0.59	0.81	0.55	0.31	0.03	0.86	1

DHc

Unfolding enthalpy change of chain

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	2.77	4.72	8.64	5.69	11.93	1.23	7.64	4.03	3.57	3.69	7.06	3.64	1.97	4.47	6.03	5.8	4.42	3.45	13.46	14.41
Normalized value	0.12	0.26	0.56	0.34	0.81	0	0.49	0.21	0.18	0.19	0.44	0.18	0.06	0.25	0.36	0.35	0.24	0.17	0.93	1

-TDSc

Unfolding entropy change of chain

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-2.25	-1.83	-5.92	-2.11	-8.71	-0.55	-3.69	-4.42	-1.7	-4.04	-5.93	-0.39	-2.36	-0.78	-0.78	-2.38	-2.68	-3.64	-7.87	-7.95
Normalized value	0.78	0.83	0.34	0.79	0	0.98	0.6	0.52	0.84	0.56	0.33	1	0.76	0.95	0.95	0.76	0.72	0.61	0.1	0.09

DGc

Unfolding Gibbs free energy change

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.02	-0.08	1.08	-0.13	2.16	0.09	0.56	-0.08	-0.32	-0.08	0.53	-0.3	-0.06	-0.23	-0.71	-0.4	-0.24	-0.06	1.78	0.91
Normalized value	0.24	0.22	0.62	0.2	1	0.28	0.44	0.22	0.14	0.22	0.43	0.14	0.23	0.17	0	0.11	0.16	0.23	0.87	0.56

DHc

Unfolding enthalpy change

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.51	0.18	5.21	0.05	6.82	-0.23	0.79	0.19	-1.45	0.17	2.89	-2.03	0.02	-1.76	-4.4	-0.16	0.04	0.3	4.47	3.73
Normalized value	0.44	0.41	0.86	0.4	1	0.37	0.46	0.41	0.26	0.41	0.65	0.21	0.39	0.24	0	0.38	0.4	0.42	0.79	0.72

-TDSc

Unfolding entropy change

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.54	-0.26	-4.14	-0.19	-4.66	0.31	-0.23	-0.27	1.13	-0.24	-2.36	1.74	-0.08	1.53	3.69	-0.24	-0.28	-0.36	-2.69	-2.82
Normalized value	0.49	0.53	0.06	0.54	0	0.6	0.53	0.53	0.69	0.53	0.28	0.77	0.55	0.74	1	0.53	0.52	0.51	0.24	0.22

Volume (number of non-hydrogen side chain atoms)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1	4	2	5	7	0	6	4	5	4	4	4	3	5	7	2	3	3	10	8
Normalized value	0.1	0.4	0.2	0.5	0.7	0	0.6	0.4	0.5	0.4	0.4	0.4	0.3	0.5	0.7	0.2	0.3	0.3	1	0.8

Shape (position of branch point in aside-chain)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0	2	0	3	2	0	2	1	0	2	0	2	0	3	5	0	1	1	2	2
Normalized value	0	0.4	0	0.6	0.4	0	0.4	0.2	0	0.4	0	0.4	0	0.6	1	0	0.2	0.2	0.4	0.4

Flexibility (number of side-chain dihedral angles)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0	2	1	3	2	0	2	2	4	2	3	2	0	3	5	1	1	1	2	2
Normalized value	0	0.4	0.2	0.6	0.4	0	0.4	0.4	0.8	0.4	0.6	0.4	0	0.6	1	0.2	0.2	0.2	0.4	0.4

Pf-s

Backbone dihedral probability

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.65	2.6	0.95	0.8	0.55	3.55	2.8	0.05	1.7	0.35	0.55	5.25	0	1.4	1.45	1.1	0.05	0.1	0.65	0.95
Normalized value	0.12	0.5	0.18	0.15	0.1	0.68	0.53	0.01	0.32	0.07	0.1	1	0	0.27	0.28	0.21	0.01	0.02	0.12	0.18

ARGP820101

Hydrophobicity index (Argos et al. 1982)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.84	1.27	0.59	0.57	1.15	0.94	0.81	1.29	0.86	1.1	0.88	0.66	0.8	1.02	1.04	1.05	1.2	1.56	1.15	1.39
Normalized value	0.23	0.4	0.17	0.18	0.76	0.03	0.23	0.84	0.43	0.58	0.45	0.02	0.74	0	0.23	0.02	0.02	0.5	1	1

BIGC670101

Residue volume (Bigelow 1967)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.91	0.93	1.4	0.97	0.72	1.51	0.9	0.65	0.82	0.59	0.58	1.64	1.66	0.94	1	1.23	1.04	0.6	0.67	0.92
Normalized value	0.16	0.5	0.5	0.63	0.84	0.27	0.68	0.75	0.78	0.75	0.72	0.56	0.54	0.66	0.81	0.4	0.53	0.63	1	1

BIOV880102

Information value for accessibility; average fraction 23% (Biou et al. 1988)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	44	90	-91	-139	148	-8	47	100	-188	108	121	-72	-36	-117	-68	-60	-54	117	163	22
Normalized value	0.66	0.79	0.28	0.14	0.96	0.51	0.67	0.82	0	0.8	0.85	0.16	0.29	0	0	0	0	0.72	1	1

BURA740102

Normalized frequency of extended structure (Burgess et al. 1974)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	8.1	5.5	13	12.3	5.2	9	10.4	5.2	11.3	4.9	5.7	11.6	8	10.5	10.5	9.2	8.6	5.9	5.4	6.2
Normalized value	0.26	1	0.09	0.19	0.25	0.24	0.12	0.35	0.19	0.34	0.31	0.15	0.28	0.26	0.3	0.29	0.33	0.45	0.16	0.37

CHAM820101

Polarizability parameter (Charton-Charton 1982)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	31	55	54	83	132	3	96	111	119	111	105	56	32.5	85	124	32	61	84	170	136
Normalized value	0.11	0.31	0.26	0.37	0.71	0	0.32	0.26	0.31	0.26	0.31	0.19	0.18	0.25	0.41	0.09	0.15	0.2	0.58	0.42

CHOC760101

Residue accessible surface area in tripeptide (Chothia 1976)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1	0.1	6.5	6.2	1.4	1.1	2.8	0.8	5.3	0.8	0.7	2.2	0.9	2.1	2.3	1.7	1.5	0.9	1.9	2.1
Normalized value	0.22	0.53	0.59	0.74	0.82	0.29	0.76	0.69	0.78	0.67	0.73	0.63	0.57	0.71	0.88	0.45	0.55	0.61	1	1

CHOP780202

Normalized frequency of beta-sheet (Chou-Fasman 1978b)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.86	1.39	0.69	0.66	1.16	0.7	1.06	1.31	0.77	1.01	1.06	0.74	1.16	0.89	0.98	1.09	1.24	1.4	1.17	1.28
Normalized value	0.35	0.62	0.14	0.15	0.79	0.39	0.47	0.94	0.38	0.74	0.58	0.48	0.26	0.61	0.51	0.39	0.67	1	0.92	1

CHOP780204

Normalized frequency of N-terminal helix (Chou-Fasman 1978b)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.78	0.6	1.5	0.97	0.67	1.73	0.83	0.4	1.01	0.57	0.3	1.56	1.55	0.78	1.06	1.19	1.09	0.44	0.74	1.14
Normalized value	0.43	0.12	0.82	1	0.26	0.34	0.32	0.29	0.29	0.24	0.31	0.37	1	0.82	0.24	0.46	0.71	0.36	1	0.64

DAYM780201

Relative mutability (Dayhoff et al. 1978b)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.09	0.5	0.77	0.92	0.5	1.25	0.67	0.66	1.25	0.44	0.45	1.14	2.96	0.83	0.97	1.21	1.33	0.56	0.62	0.94
Normalized value	0.71	0.14	0.79	0.76	0.31	0.36	0.49	0.72	0.42	0.3	0.7	1	0.47	0.77	0.54	1	1	1	0.44	1

EISD860101

Solvation free energy (Eisenberg-McLachlan 1986)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.87	1.52	0.66	0.67	2.87	0.1	0.87	3.15	1.64	2.17	1.67	0.09	2.77	0	0.85	0.07	0.07	1.87	3.77	2.67
Normalized value	0.59	0.53	0.19	0.29	0.94	0.45	0.58	0.85	0.33	0.85	0.96	0.32	0.7	0.4	0	0	0.2	0.58	1	1

FASG760101

Molecular weight (Fasman 1976)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	5.3	1.3	3.6	3.3	2.3	4.8	1.4	3.1	4.1	4.7	1.1	3	2.5	2.4	2.6	4.5	3.7	4.2	0.8	2.3
Normalized value	0.11	0.59	0.65	0.72	0.81	0.37	0.76	0.64	0.72	0.64	0.73	0.65	0.56	0.72	0.85	0.51	0.58	0.57	1	1

FASG760102

Melting point (Fasman 1976)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.81	1.17	0.71	0.53	1.2	0.88	0.92	1.48	0.77	1.24	1.05	0.62	0.61	0.98	0.85	0.92	1.18	1.66	1.18	1.23
Normalized value	0.72	0.52	0.78	0.72	0.83	0.84	0.8	0.83	0.65	0.98	0.82	0.69	0.64	0.54	0.69	0.66	0.74	0.85	0.82	1

FAUJ830101

Hydrophobic parameter pi (Fauchere-Pliska 1983)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.45	0.7	0.91	1.29	1.2	0.53	1.13	1.23	1.27	1.56	1.83	0.64	0.21	1.14	1.15	0.48	0.77	1.1	1.17	0.74
Normalized value	0.4	0.78	0.07	0.11	0.86	0.31	0.35	0.86	0.01	0.83	0.69	0.13	0.53	0.24	0	0	0.12	0.54	1	0.96

FAUJ880101

Graph shape index (Fauchere et al. 1988)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.041	0.96	1.033	1.094	0.93	1.142	0.982	1.002	1.093	0.967	0.947	1.117	1.055	1.165	1.038	1.169	1.073	0.982	0.925	0.961
Normalized value	0.31	0.42	0.38	0.37	0.7	0	0.71	1	0.51	0.71	0.64	0.44	0.73	0.43	0.64	0.36	0.83	1	1	1

FAUJ880106

STERIMOL maximum width of the side chain (Fauchere et al. 1988)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	4.6	-1	5.7	5.6	3.2	7.6	4.5	2.6	7.9	3.25	1.4	5.9	7	6.1	6.5	5.25	4.8	3.4	4	4.35
Normalized value	0.18	0.49	0.55	0.48	0.89	0.13	0.84	0.51	0.72	0.66	0.71	0.64	0.63	0.52	0.93	0.39	0.46	0.46	0.88	1

GEIM800105

Beta-strand indices (Geisow-Roberts 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	4.32	1.73	6.04	6.17	2.59	6.09	5.66	2.31	7.92	3.93	2.44	6.24	7.19	6.13	6.55	5.37	5.16	3.31	2.78	3.58
Normalized value	0.27	0.77	0.25	0.25	0.69	0.53	0.43	0.79	0.47	0.65	0.48	0.31	0.42	0.59	0.6	0.61	0.73	1	0.79	1

GEIM800108

Aperiodic indices (Geisow-Roberts 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.48	-0.32	-0.75	-0.71	1.03	0	-0.51	0.81	-0.09	1.02	0.81	-0.87	2.03	-0.32	-0.06	0.05	-0.35	0.56	0.66	1.24
Normalized value	0.31	0.46	0.81	0.49	0.31	0.89	0.44	0.25	0.4	0.24	0.24	0.99	1	0.71	0.77	1	1	0.47	0.57	0.89

GRAR740102

Polarity (Grantham 1974)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.5	-1	2.5	2.5	-2.5	0	-0.5	-1.8	3	-1.8	-1.3	0.2	-1.4	0.2	3	0.3	-0.4	-1.5	-3.4	-2.3
Normalized value	0.4	0.4	1	1	0.43	0.77	0.89	0.43	0.97	0.4	0.47	1	0.75	1	1	1	1	0.95	0.86	1

GRAR740103

Volume (Grantham 1974)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.92	1.16	0.48	0.61	1.25	0.61	0.93	1.81	0.7	1.3	1.19	0.6	0.4	0.95	0.93	0.82	1.12	1.81	1.54	1.53
Normalized value	0.17	0.32	0.32	0.49	0.78	0.02	0.56	0.65	0.7	0.65	0.62	0.33	0.19	0.5	0.73	0.19	0.36	0.49	1	1

HOPA770101

Hydration number (Hopfinger 1971) Cited by Charton-Charton (1982)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.9	1.24	0.47	0.62	1.23	0.56	1.12	1.54	0.74	1.26	1.09	0.62	0.42	1.18	1.02	0.87	1.3	1.53	1.75	1.68
Normalized value	0.14	0	1	1	0.26	0.21	0.53	0.15	1	0.35	0.3	0.96	0.39	0.91	1	0.81	0.71	0.43	0.9	1

ISOY800102

Normalized relative frequency of extended structure (Isogai et al. 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	12.97	14.63	10.85	11.89	14	12.43	12.16	15.67	11.36	14.9	14.39	11.42	11.37	11.76	11.72	11.23	11.69	15.71	13.93	13.42
Normalized value	0.27	0.99	0.37	0.34	0.79	0.38	0.7	0.92	0.44	0.65	0.7	0.42	0.79	0.55	0.63	0.73	0.86	1	0.89	1

ISOY800103

Normalized relative frequency of bend (Isogai et al. 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.86	1.17	0.72	0.62	1.16	0.97	1.06	1.24	0.79	0.98	1.08	0.74	1.22	0.89	0.94	1.04	1.18	1.33	1.07	1.25
Normalized value	0.34	0.21	0.85	0.5	0.3	1	0.46	0.14	0.61	0.3	0.11	1	1	0.62	0.88	1	0.95	0.32	0.61	1

ISOY800104

Normalized relative frequency of bend R (Isogai et al. 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1	1.09	1.39	1.04	0.65	0.46	0.71	0.68	1.05	1.01	0.36	0.87	1.95	1.13	1.18	1.56	1.23	0.58	1.1	0.87
Normalized value	0.26	0.09	0.24	0.29	0.14	0.4	0.2	0.2	0.4	0.12	0.13	0.37	1	0.6	0.71	0.9	1	0.52	0.58	0.93

JOND750101

Hydrophobicity (Jones 1975)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	2.36	3.36	1.67	1.74	4.37	2.06	2.41	4.17	1.23	3.93	4.22	1.7	1.89	1.75	1.92	1.81	2.04	3.49	3.82	2.91
Normalized value	0.23	0.4	0.18	0.18	0.76	0.03	0.23	0.84	0.44	0.58	0.44	0.02	0.73	0	0.23	0.02	0.02	0.5	1	1

JUKT750101

Amino acid distribution (Jukes et al. 1975)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.96	1.13	0.9	0.33	1.37	0.9	0.87	1.54	0.81	1.26	1.29	0.72	0.75	1.18	0.67	0.77	1.23	1.41	1.13	1.07
Normalized value	1	0.13	0.74	0.68	0.47	1	0.28	0.65	0.87	1	0.22	0.66	0.54	0.52	0.57	1	0.88	1	0.31	1

KANM800102

Average relative probability of beta-sheet (Kanehisa-Tsong 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.72	1.01	1.04	0.75	0.58	1.35	0.76	0.8	0.84	0.63	0.62	1.38	1.43	0.81	1.33	1.34	1.03	0.83	0.87	1.35
Normalized value	0.25	0.65	0.33	0.2	0.68	0.47	0.49	0.88	0.39	0.71	0.58	0.29	0.28	0.53	0.45	0.49	0.67	1	0.95	1

KANM800103

Average relative probability of inner helix (Kanehisa-Tsong 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.288	0.533	0.271	0.262	0.318	0.312	0.2	0.411	0.265	0.4	0.375	0.229	0.34	0.327	0.362	0.354	0.388	0.495	0.231	0.429
Normalized value	0.77	0.3	0.43	0.67	0.61	0.2	0.57	0.63	0.66	0.83	1	0.45	0.01	0.97	0.98	0.4	0.65	0.94	1	0.74

KARP850101

Flexibility parameter for no rigid neighbors (Karplus-Schulz 1985)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.61	1.07	0.46	0.47	2.02	0.07	0.61	2.22	1.15	1.53	1.18	0.06	1.95	0	0.6	0.05	0.05	1.32	2.65	1.88
Normalized value	0.48	0.7	0.8	0.89	0.66	0.96	0.73	0.76	0.89	0.71	0.68	0.93	0.84	0.99	0.81	1	1	0.97	0.86	0.93

KRIW710101

Side chain interaction parameter (Krigbaum-Rubin 1971)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.22	4.66	-4.12	-3.64	5.27	-1.62	1.28	5.58	-4.18	5.01	3.51	-2.65	-3.03	-2.76	-0.93	-2.84	-1.2	4.45	5.2	2.15
Normalized value	0.63	0	0.72	0.71	0.41	0.96	0.57	0.33	1	0.46	0.2	0.84	1	0.94	1	1	1	0.78	0.92	1

KRIW790101

Side chain interaction parameter (Krigbaum-Komoriya 1979)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.491	-0.67	-0.356	-0.371	-0.729	-0.534	-0.54	-0.762	-0.3	-0.65	-0.659	-0.382	-0.463	-0.405	-0.554	-0.455	-0.515	-0.728	-0.839	-0.656
Normalized value	0.42	0.17	0.76	0.77	0.31	0.76	0.71	0.28	1	0.54	0.32	0.86	1	0.93	1	1	1	0.92	0.77	1

LAWE840101

Transfer free energy CHP/water (Lawson et al. 1984)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.46	0.2	-0.33	0.48	0.52	0.64	-1.31	3.28	-1.71	0.43	0.15	1.31	-0.58	-1.12	-1.54	-0.83	-1.52	0.54	1.25	-2.21
Normalized value	0.13	0.19	0.04	0.06	0.66	0.3	0.12	0.58	0.27	0.65	0.58	0	1	0.02	0.18	0.25	0	0.45	0.53	1

LEVM760101

Hydrophobic parameter (Levitt 1976)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.046	0.128	0.105	0.151	0.29	0	0.23	0.186	0.219	0.186	0.221	0.134	0.131	0.18	0.291	0.062	0.108	0.14	0.409	0.298
Normalized value	0.45	0.38	0.92	0.92	0.14	0.53	0.45	0.25	1	0.25	0.33	0.56	0.31	0.56	1	0.84	0.68	0.43	0	0

LIFS790101

Conformational preference for all beta-strands (Lifson-Sander 1979)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	4.55	-0.78	2.85	5.16	4.37	9.14	4.48	2.1	10.68	3.24	2.18	5.56	5.14	4.15	5.97	6.78	8.6	3.81	1.97	2.4
Normalized value	0.37	0.55	0.08	0.31	0.68	0.31	0.49	1	0.36	0.71	0.64	0.3	0.19	0.5	0.49	0.43	0.6	1	1	1

LIFS790103

Conformational preference for antiparallel beta-strands (Lifson-Sander 1979)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	7.62	10.93	6.18	6.38	8.99	7.31	7.85	9.99	5.72	9.37	9.83	6.17	6.64	6.67	6.81	6.93	7.08	10.38	8.41	8.53
Normalized value	0.36	0.63	0.08	0.32	0.69	0.29	0.62	0.87	0.4	0.71	0.61	0.32	0.2	0.66	0.56	0.47	0.73	0.87	1	1

MANP780101

Average surrounding hydrophobicity (Manavalan-Ponnuswamy 1978)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	2.63	3.36	2.29	2.31	3.02	2.55	2.57	3.08	2.12	2.98	3.18	2.27	2.46	2.45	2.45	2.6	2.55	3.21	2.85	2.79
Normalized value	0.44	0.93	0.68	0.75	0.89	0.79	0.77	1	0.72	0.95	0.91	0.72	0.72	0.74	0.74	0.71	0.74	1	1	1

MAXF760102

Normalized frequency of extended structure (Maxfield-Scheraga 1976)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	3.7	3.03	2.6	3.3	6.6	3.13	3.57	7.69	1.79	5.88	5.21	2.12	2.12	2.7	2.53	2.43	2.6	7.14	6.25	3.03
Normalized value	0.34	0.84	0.39	0.28	0.84	0.66	0.74	0.91	0.48	0.67	0.76	0.44	0.89	0.58	0.63	0.72	0.86	1	0.81	1

MAXF760106

Normalized frequency of alpha region (Maxfield-Scheraga 1976)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.78	0.8	1.41	1	0.58	1.64	0.69	0.51	0.96	0.59	0.39	1.28	1.91	0.97	0.88	1.33	1.03	0.47	0.75	1.05
Normalized value	0.4	0.46	0.65	0.43	0.18	0.16	0.31	0.29	0.5	0.48	0.11	0.41	1	0.7	0.74	1	1	0.47	1	0.85

MIYS850101

Effective partition energy (Miyazawa-Jernigan 1985)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.934	0.9	0.994	0.986	0.773	1.015	0.882	0.766	1.04	0.825	0.804	0.986	1.047	1.047	0.962	1.056	1.008	0.825	0.848	0.931
88	Normalized value	0.36	0.75	0.33	0.35	1	0.45	0.54	0.99	0.23	0.93	1	0.41	0.46	0.42	0.47	0.44	0.5	0.91	1	1

NAGK730102

Normalized frequency of bata-structure (Nagano 1973)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.941	0.866	1.071	1.1	0.723	1.055	0.911	0.742	1.232	0.798	0.781	1.038	1.093	1.15	1.112	1.082	1.043	0.817	0.867	1.05
Normalized value	0.52	0.66	0.47	0	0.89	0.58	0.56	1	0.57	0.89	0.91	0.51	0.53	0.84	0.48	0.55	0.87	1	1	1

NAGK730103

Normalized frequency of coil (Nagano 1973)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	17.05	28.84	19.27	20.12	16.26	38.14	23.07	16.66	16.46	10.89	20.61	34.81	23.94	15.42	21.25	19.95	18.92	17.06	23.36	26.49
Normalized value	0.16	0.67	0.69	0.46	0.33	0.94	0.47	0.5	0.53	0.37	0.36	0.96	1	0.54	0.98	0.99	0.73	0.56	0.6	1

NISK860101

14 A contact number (Nishikawa-Ooi 1986)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	115	135	150	190	210	75	195	175	200	170	185	160	145	180	225	115	140	155	255	230
Normalized value	0.41	0.91	0.01	0.06	0.97	0.26	0.56	1	0	0.98	0.79	0.05	0	0.01	0.24	0	0	0.86	1	1

OOBM770103

Long range non-bonded energy per atom (Oobatake-Ooi 1977)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-2.3	4.4	-4.4	-5	2.6	-4.2	-2.5	6.7	-3.3	2.3	2.3	-4.1	-1.8	1.2	0.4	-1.7	1.3	6.8	-1	4
Normalized value	0.65	0.11	0.33	0.32	0.07	0.21	0.2	0.05	0.36	0.13	0.12	0.31	0.25	0.29	0.19	0.26	0.22	0.07	0	0

OOBM850103

Optimized transfer energy parameter (Oobatake et al. 1985)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.67	-2	1.57	1.78	-3.24	0	1.09	-3.02	2.46	-3.02	-1.67	2.27	-1.75	2.12	3.89	0.1	-0.42	-2.18	-2.86	0.98
Normalized value	0.49	0.44	0.34	0.49	0.5	0.52	0.16	1	0.14	0.75	0.67	1	0.47	0.32	0.19	0.4	0.2	0.79	1	0

OOBM850105

Optimized side chain interaction parameter (Oobatake et al. 1985)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.73	0.7	0.54	0.55	2.65	0	1.1	2.97	1.5	2.49	1.3	-0.01	2.6	-0.1	0.73	0.04	0.44	1.69	3	2.97
Normalized value	0.47	0	0.27	0.48	0.41	0.86	0.42	0.2	1	0.38	0.25	0.65	0.6	0.48	0.69	0.79	1	1	0.82	1

PONP800102

Average gain in surrounding hydrophobicity (Ponnuswamy et al. 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	7	5.5	13	12.5	5	7.9	8.4	4.9	10.1	4.9	5.3	10	6.6	8.6	9.1	7.5	6.6	5.6	5.3	5.7
Normalized value	0.36	1	0.58	0.6	0.86	0.69	0.75	0.96	0.53	0.9	0.95	0.58	0.63	0.63	0.64	0.66	0.67	1	0.99	1

PONP800103

Average gain ratio in surrounding hydrophobicity (Ponnuswamy et al. 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.83	1.19	0.54	0.37	1.38	0.75	0.87	1.6	0.74	1.3	1.05	0.89	0.55	1.1	0.93	0.75	1.19	1.7	1.37	1.47
Normalized value	0.41	1	0.67	0.68	0.93	0.76	0.77	0.95	0.61	0.92	0.99	0.66	0.73	0.73	0.73	0.78	0.76	1	1	1

PONP800107

Accessibility reduction ratio (Ponnuswamy et al. 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	6.8	8.3	7	4.9	8.3	6.4	9.2	10	7.5	12.2	8.4	6.2	6.9	8.5	0	8	7	9.4	5.7	6.8
Normalized value	0.32	0.37	0.31	0.41	0.85	0.38	0.44	1	0.22	0.82	0.72	0.27	0.27	0.36	0.33	0.32	0.34	1	1	1

PRAM900104

Relative frequency in reverse-turn (Prabhakaran 1990)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.83	1.48	0.64	0.65	2.75	0.1	1.1	3.07	1.6	2.52	1.4	0.09	2.7	0	0.83	0.14	0.54	1.79	0.31	2.97
Normalized value	0.26	0.33	0.7	0.45	0.2	0.84	0.29	0.18	0.45	0.24	0.12	0.65	1	0.7	0.63	1	0.98	0.38	0.68	1

RACS770101

Average reduced distance for C-alpha (Rackovsky-Scheraga 1977)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	11.5	13.46	11.68	13.57	19.8	3.4	13.69	21.4	15.71	21.4	16.25	12.82	17.43	14.45	14.28	9.47	15.77	21.57	21.67	18.03
Normalized value	0.58	0.67	0.87	0.85	0.41	0.94	0.73	0.55	0.98	0.64	0.61	0.89	0.99	0.99	0.86	1	1	0.71	0.74	0.88

100

RACS770102

Average reduced distance for side chain (Rackovsky-Scheraga 1977)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	9.9	2.8	2.8	3.2	18.8	5.6	8.2	17.1	3.5	17.6	14.9	5.4	14.8	9	4.6	6.9	9.5	14.3	17.1	15
Normalized value	0.43	0.54	0.8	0.84	0.37	0.8	0.63	0.43	1	0.55	0.53	0.86	0.93	1	1	1	0.99	0.66	0.73	1

101

RACS820113

Value of theta(i) (Rackovsky-Scheraga 1982)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.29	0.66	2.02	2.44	0.61	0.76	0.73	0.67	0.66	0.58	0.71	0.81	2.01	1.22	0.44	0.74	1.08	0.61	1.47	0.68
Normalized value	0.23	0.75	0.5	0.52	0.42	1	0.66	0.48	0.47	0.31	0.59	1	0.9	0.58	0.8	0.75	0.71	0.64	0.88	1

102

ROBB760105

Information measure for extended (Robson-Suzuki 1976)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.77	-0.23	-0.15	-0.27	-0.41	0	-0.06	-0.23	-0.65	-0.62	-0.5	-0.07	3	-0.33	-0.68	-0.35	-0.11	-0.14	-0.45	-0.17
Normalized value	0.23	0.8	0.05	0	0.62	0	0.15	0.99	0.07	0.59	0.59	0	0	0.34	0.25	0	0.29	1	0	1

103

ROSM880102

Side chain hydropathy corrected for solvation (Roseman 1988)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.984	0.906	1.068	1.094	0.915	1.031	0.95	0.927	1.102	0.935	0.952	1.048	1.049	1.037	1.008	1.046	0.997	0.931	0.904	0.929
Normalized value	0.36	0.17	0.67	0.7	0	0.44	0.59	0	0.79	0	0.18	0.76	0.16	0.74	1	0.77	0.63	0.18	0	0.98

104

SIMZ760101

Transfer free energy (Simon 1976) Cited by Charton-Charton (1982)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	58	116	-97	-131	92	-11	-73	107	-24	95	78	-93	-79	-139	-184	-34	-7	100	59	-11
Normalized value	0.27	0.26	0.21	0.21	0.89	0.03	0.39	0.99	0.52	0.84	0.45	0.03	0.87	0	0.24	0.01	0.15	0.56	1	1

105

WOEC730101

Polar requirement (Woese 1973)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	51	137	-78	-115	108	-13	-55	106	-205	103	73	-84	-79	-128	-144	-26	-3	108	69	11
Normalized value	0.26	0.41	1	1	0.48	0.78	0.83	0.47	1	0.48	0.52	1	0.72	0.94	1	1	1	0.98	0.93	1

106

YUTK870102

Unfolding Gibbs energy in water pH9.0 (Yutani et al. 1987)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	32	182	-29	-74	132	-22	-25	106	-124	104	82	-73	-82	-95	-95	-34	20	113	118	44
Normalized value	0.56	0.68	0.57	0.4	0.68	0.52	0.75	0.82	0.61	1	0.89	0.66	0.73	0.9	0	0.85	0.74	1	0.84	1

107

ZIMJ680101

Hydrophobicity (Zimmerman et al. 1968)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	24	194	0	-57	131	-28	-31	102	-9	103	90	-76	-85	-87	-79	-36	34	111	116	43
Normalized value	0.27	0.48	0.21	0.21	0.9	0.03	0.36	1	0.54	0.85	0.47	0.03	0.91	0	0.28	0.05	0.18	0.6	0.1	1

108

ZIMJ680102

Bulkiness (Zimmerman et al. 1968)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	6.77	0.31	8.57	12.93	1.92	7.95	2.8	2.72	10.2	4.43	1.87	5.5	4.79	5.24	6.87	5.41	5.36	3.57	0.54	2.26
Normalized value	0.44	0.61	0.53	0.62	0.91	0.14	0.63	0.99	0.72	0.99	0.75	0.59	0.8	0.66	0.66	0.43	0.73	1	1	1

109

ZIMJ680105

RF rank (Zimmerman et al. 1968)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	7.43	0.42	8.71	5.86	1.18	9.4	1.49	1.76	9.67	2.74	0.6	9.12	5.6	5.42	4.51	9.6	8.95	3.1	1.18	3.26
Normalized value	0.44	0.13	0.14	0.16	1	0.31	0.46	0.97	0.19	1	0.87	0.31	0.86	0.52	0.26	0.4	0.55	0.84	1	1

110

ONEK900102

Helix formation parameters (delta delta G) (O'Neil-DeGrado 1990)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.78	0.55	1.35	1.45	0.47	0.68	0.99	0.47	1.1	0.56	0.66	1.2	0.69	1.19	1.58	1	1.05	0.51	0.7	1
Normalized value	0	0.12	0.14	0.11	0.07	0.18	0.17	0.12	0.01	0.02	0.05	0.17	1	0.21	0	0.07	0.23	0.21	0	0

111

VINM940101

Normalized flexibility parameters (B-values) average (Vihinen et al. 1994)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	2.18	3.89	1.75	1.89	5.88	1.17	2.51	4.5	2.12	4.71	3.63	1.85	2.09	2.16	2.71	1.66	2.18	3.77	6.46	5.01
Normalized value	0.4	0.72	0.95	0.99	0.73	0.9	0.78	0.75	1	0.82	0.85	1	1	0.99	0.94	1	0.99	0.88	0.84	0.88

112

NADH010101

Hydropathy scale based on self-information values in the two-state model (5% accessibility) (Naderi-Manesh et al. 2001)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.79	2.22	2.33	2.52	4.84	0.7	3.06	4.59	2.5	4.72	3.91	2.83	2.45	2.37	3.2	1.82	2.45	3.67	5.64	4.46
Normalized value	0.81	1	0.3	0.18	0.95	0.59	0.38	1	0.56	0.98	0.92	0.32	0.37	0.16	0	0	0.04	1	1	0

113

NADH010102

Hydropathy scale based on self-information values in the two-state model (9% accessibility) (Naderi-Manesh et al. 2001)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	13.4	22.6	8.2	7.3	23.9	7	11.3	20.3	6.1	20.8	15.7	7.6	9.9	8.5	8.5	8.2	10.3	19.5	24.5	19.5
Normalized value	0.75	1	0.41	0.29	1	0.61	0.48	0.99	0	0.98	0.86	0.24	0.26	0.06	0	0	0	1	1	1

114

NADH010104

Hydropathy scale based on self-information values in the two-state model (20% accessibility) (Naderi-Manesh et al. 2001)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	91.5	114.4	135.2	154.6	198.8	67.5	163.2	162.6	162.5	163.4	165.9	138.3	123.4	156.4	196.1	102	126	138.4	209.8	237.2
Normalized value	0.51	1	0.37	0.2	1	0.42	0.41	0.95	0	0.93	0.83	0.1	0.06	0	0	0	0.17	0.96	1	1

115

NADH010105

Hydropathy scale based on self-information values in the two-state model (25% accessibility) (Naderi-Manesh et al. 2001)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.12	0.59	-0.83	-0.92	0.67	1.2	-0.93	1.16	-0.8	1.18	0.55	-0.83	0.54	-0.78	-2.55	-0.05	-0.02	1.13	-0.19	-0.23
Normalized value	0.4	1	0.4	0.14	1	0.29	0.28	0.93	0.38	0.94	0.87	0.05	0.01	0	0	0	0.29	0.96	1	1

116

FUKS010102

Surface composition of amino acids in intracellular proteins of mesophiles (percent) (Fukuchi-Nishikawa 2001)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.38	1.43	0.52	0.71	1.72	1.34	0.66	2.32	0.15	1.47	1.78	0.37	0.85	0.22	0	0.86	0.89	1.99	0.82	0.47
Normalized value	0.51	0	0.66	1	0.19	0.78	0.27	0.27	1	0.64	0.27	0.8	0.7	0.76	1	1	1	1	0.24	1

117

FUKS010103

Surface composition of amino acids in extracellular proteins of mesophiles (percent) (Fukuchi-Nishikawa 2001)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.27	-1.05	0.81	1.17	-1.43	-0.16	0.28	-0.77	1.7	-1.1	-0.73	0.81	-0.75	1.1	1.87	0.42	0.63	-0.4	-1.57	-0.56
Normalized value	0.76	0	0.9	0.61	0.12	0.97	0.15	0.18	1	0.29	0.06	0.95	0.58	0.56	0.47	1	1	0.95	0.36	1

118

KUHL950101

Hydrophilicity scale (Kuhn et al. 1995)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.414	0.162	-1.31	-1.218	1.938	-0.684	-0.63	1.237	-0.67	1.215	1.02	-0.916	-0.503	-0.905	-0.584	-0.563	-0.289	0.899	0.514	1.699
Normalized value	0.28	0.21	0.83	0.91	0.19	0.35	0.58	0.2	0.65	0.27	0.34	0.73	0.36	0.72	1	0.94	1	0.39	0.63	1

119

ZHOH040101

The stability scale from the knowledge-based atom-atom potential (Zhou-Zhou 2004)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.26	0.83	-1.3	-0.73	1.09	-0.4	-0.18	1.1	-1.01	1.52	1.09	-0.46	-0.62	-0.83	0.08	-0.55	-0.71	1.15	-0.13	0.69
Normalized value	0.19	0.59	0.25	0.27	0.91	0.16	0.37	0.69	0.31	0.72	0.55	0.27	0.31	0.32	0.41	0.24	0.32	0.57	1	1

120

ZHOH040102

The relative stability scale extracted from mutation experiments (Zhou-Zhou 2004)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-1.35	4.37	-11.88	-4.56	11.35	-5.82	6.54	10.93	-11.92	9.88	7.47	-10.96	-10.86	-1.34	-3.89	-6.21	-4.83	8.2	1.8	7.61
Normalized value	0.22	0.37	0.39	0.42	0.85	0.09	0.54	0.81	0.43	0.83	0.69	0.49	0.43	0.41	0.56	0.31	0.43	0.65	1	1

121

ZHOH040103

Buriability (Zhou-Zhou 2004)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.37	-4.47	8.93	4.04	-7.96	3.39	-1.65	-7.92	7.7	-8.68	-7.13	6.29	6.25	3.88	1.33	4.08	4.02	-6.94	0.79	-4.73
Normalized value	0.4	0.92	0.32	0.29	0.98	0.28	0.46	0.83	0.24	0.85	0.64	0.3	0.4	0.34	0.34	0.33	0.41	0.79	1	1

122

PONJ960101

Average volumes of residues (Pontius et al. 1996)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.02	-0.96	0.72	0.74	-2.22	0.38	0	-1.89	1.01	-2.29	-1.36	0.63	0.47	0.56	0.44	0.55	0.25	-1.34	-1.28	-0.88
Normalized value	0.14	0.48	0.57	0.65	0.84	0.28	0.69	0.69	0.68	0.69	0.7	0.58	0.52	0.66	0.83	0.43	0.53	0.58	0.88	1

123

WOLR790101

Hydrophobicity index (Wolfenden et al. 1979)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	-0.21	-6.04	1.36	2.3	-4.65	0	-1.23	-4.81	3.88	-4.68	-3.66	0.96	0.75	1.52	2.11	1.74	0.78	-3.5	-3.32	-1.01
Normalized value	0.98	0.84	0.46	0.43	0.86	1	0.43	0.99	0.47	1	0.84	0.47	0.84	0.48	0	0.13	0.15	1	0.03	0

124

OLSK800101

Average internal preferences (Olsen 1980)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	100	20	106	102	41	49	66	96	56	40	94	134	56	93	65	120	97	74	18	41
Normalized value	0.59	0.62	0.22	0.31	0.74	0.58	0.28	1	0.08	0.74	0.89	0.19	0.43	0.11	0	0.43	0.45	1	0.82	0.47

125

KIDA850101

Hydrophobicity-related index (Kidera et al. 1985)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.67	0.38	-1.2	-0.76	2.3	0	0.64	1.9	-0.57	1.9	2.4	-0.6	1.2	-0.22	-2.1	0.01	0.52	1.5	2.6	1.6
Normalized value	0.38	0.15	0.69	0.8	0.04	0.41	0.54	0.23	0.95	0.14	0.24	0.69	0.24	0.78	1	0.77	0.86	0.46	0	0

126

CORJ870102

SWEIG index (Cornette et al. 1987)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	89.09	121.15	133.1	147.13	165.19	75.07	155.16	131.17	146.19	131.17	149.21	132.12	115.13	146.15	174.2	105.09	119.12	117.15	204.24	181.19
Normalized value	0.28	0.45	0	0	1	0.09	0.11	0.82	0.09	0.81	0.74	0	0.15	0	0	0	0	0.53	0.3	1

127

CORJ870104

PRILS index (Cornette et al. 1987)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	297	178	270	249	284	290	277	284	224	337	283	236	222	185	238	228	253	293	282	344
Normalized value	0.37	0.76	0	0.11	0.83	0.24	0.33	0.83	0	1	0.97	0.19	0.11	0	0.42	0.09	0	1	0	0.69

128

CORJ870106

ALTLS index (Cornette et al. 1987)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	0.31	1.54	-0.77	-0.64	1.79	0	0.13	1.8	-0.99	1.7	1.23	-0.6	0.72	-0.22	-1.01	-0.04	0.26	1.22	2.25	0.96
Normalized value	0.45	0.7	0	0.32	1	0.27	0.81	1	0	1	0.96	0	0	0.34	0.16	0	0	1	0.24	1

129

CORJ870108

TOTLS index (Cornette et al. 1987)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	1.28	1.77	1.6	1.56	2.94	0	2.99	4.19	1.89	2.59	2.35	1.6	2.67	1.56	2.34	1.31	3.03	3.67	3.21	2.94
Normalized value	0.57	0.24	1	0.78	0.04	0.74	0.43	0.05	1	0	0	1	1	0.98	0.75	1	1	0	0.96	0

130

MIYS990101

Relative partition energies derived by the Bethe approximation (Miyazawa-Jernigan 1999)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	2.04	3.41	3.78	3.31	6.02	1	5.66	3.49	4.87	4.45	4.8	4.37	4.31	3.53	6.24	2.7	3.17	3.17	5.9	6.72
Normalized value	0.36	0.75	0.33	0.35	1	0.45	0.54	0.99	0.23	0.93	1	0.41	0.46	0.42	0.47	0.44	0.5	0.91	1	1

131

FASG890101

Hydrophobicity index (Fasman 1989)

Amino acid	A	D	C	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Actual value	52.6	68.3	68.4	84.7	113.9	36.3	91.9	102	105.1	102	97.7	75.7	73.6	89.7	109.1	54.9	71.2	85.1	135.4	116.2
Normalized value	0.59	0	0.71	0.82	0.02	0.55	0.41	0	1	0	0	0.8	0.76	0.89	1	1	0.95	0	0	0

_________________________________________________________________________________

M. Michael Gromiha "A Statistical Model for Predicting Protein Folding Rates from Amino Acid Sequence with Structural Class Information,J. Chem. Inf. Model., 2005, 45 (2), pp 494-501"

Kawashima, S., Pokarowski, P., Pokarowska, M., Kolinski, A., Katayama, T., and Kanehisa, M."AAindex: amino acid index database, progress report 2008."Nucleic Acids Res. 36, D202-D205 (2008)."

AMINO ACID PROPERTIES