Effects of mutation	Insertion	Deletion	Missense
Disease	2455	7183	178924
Neutral	39	272	17516

Total number of transmembrane proteins in UniProt database	5195
Total number of distinct disease mutations	183395
Total number of distinct proteins in disease mutations	4797
Number of disease mutations in the interface	4728
Total number of distinct neutral mutations	17827
Total number of distinct proteins in neutral mutations	3132
Number of neutral mutations in the interface	808

Topological regions	Disease	Neutral	Total
Inside	20389	2736	23215
Membrane	5463	578	6041
Outside	35826	3254	39080
Signal	902	146	1048

No. of TM segments	No. of proteins	Disease	Neutral	Total
1	793	39792	3894	43686
2	54	1745	213	1958
3	19	1216	102	1318
4	50	2243	369	2612
5	13	412	11	423
6	48	2404	209	2613
7	115	4405	337	4742
8	11	976	109	1085
9	19	1001	318	1319
10	4	222	15	237
11	15	603	196	799
12	39	2973	427	3400
13	6	476	40	516
14	8	409	36	445
15	1	46	1	47
16	3	69	13	82
17	3	432	47	479
19	1	2	0	2
20	1	729	42	771
24	4	2367	332	2699
35	1	53	3	56

The columns represent wild-type residues. The rows represent mutated residues.
For example, to find the number of E to K mutants, locate the E-row, and then the value in the K-column.

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	0	1	795	474	2	442	0	2	0	1	0	1	521	1	0	1330	5783	5318	0	0
C	0	0	0	0	462	204	0	0	0	0	0	0	0	0	593	375	0	0	170	844
D	245	1	0	845	2	939	726	2	0	0	0	5259	0	0	0	1	0	430	0	1227
E	272	0	1640	0	0	737	1	0	8933	1	1	0	0	1071	1	0	2	396	0	0
F	0	384	0	0	0	0	1	352	0	2051	0	1	0	0	0	531	1	530	0	222
G	575	720	1810	4261	3	0	0	5	46	5	1	24	0	0	4215	2300	1	1422	436	0
H	0	0	144	0	0	0	0	0	0	174	0	362	224	447	562	0	1	0	0	1531
I	1	0	1	0	412	0	0	0	77	355	774	359	1	0	48	226	1091	1314	0	1
K	0	0	0	687	0	0	0	123	0	0	193	1709	0	262	642	0	624	0	0	0
L	0	0	0	0	2662	0	248	1133	1	0	915	0	1685	410	695	334	0	1244	78	0
M	1	0	0	0	0	0	0	2294	205	288	0	1	1	0	133	0	573	680	0	0
N	0	0	487	0	0	0	276	318	850	0	0	0	0	0	1	1188	314	0	0	218
P	483	0	0	1	47	0	778	2	2	5209	1	1	0	405	479	5283	1024	0	1	0
Q	0	0	0	440	0	0	1118	0	677	329	0	0	238	0	628	0	0	0	0	0
R	0	6026	0	2	2	824	5904	508	1376	955	281	1	436	5879	0	809	335	0	4132	1
S	237	822	0	0	4851	532	0	568	0	3269	0	1120	810	0	877	0	559	0	82	993
T	1377	0	1	1	2	0	0	1796	399	2	2856	553	638	0	263	674	0	0	0	0
V	1422	0	236	263	531	623	1	3326	2	1194	2812	1	0	0	0	0	1	0	0	0
W	1	516	0	0	0	115	0	0	1	278	0	0	0	0	447	124	0	0	0	1
Y	0	1287	188	0	260	0	753	0	0	0	0	237	0	0	0	173	0	0	0	0

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	0	0	73	62	0	116	0	0	0	4	1	0	94	0	1	139	576	464	0	0
C	0	0	0	0	31	20	0	0	1	0	0	0	0	1	82	59	0	0	20	77
D	42	0	0	156	0	133	68	0	0	2	0	284	0	2	3	5	0	40	0	76
E	63	0	139	0	0	109	0	0	342	4	0	3	0	108	2	1	2	43	0	0
F	0	24	1	0	0	1	1	24	0	217	0	2	0	0	0	96	0	43	0	37
G	91	30	148	108	0	0	0	0	0	1	0	1	0	0	271	277	0	100	35	0
H	0	0	19	1	0	0	0	0	0	22	0	37	21	98	124	1	0	0	0	117
I	0	0	0	0	63	0	0	0	8	69	113	38	0	0	4	21	280	396	0	0
K	0	0	0	120	0	0	0	5	0	0	16	111	0	45	127	0	39	1	0	0
L	3	0	2	0	231	0	21	85	0	0	52	0	178	34	79	49	3	245	25	4
M	0	0	0	0	0	0	0	117	25	64	0	0	0	1	22	0	150	188	0	0
N	0	0	113	6	1	0	48	32	156	0	0	0	0	0	0	287	49	0	0	21
P	95	0	0	0	0	0	59	0	0	408	0	0	0	49	106	275	91	0	0	0
Q	0	0	2	75	0	1	117	0	42	25	0	0	32	0	172	0	0	0	3	0
R	4	360	2	6	0	153	475	13	113	119	18	1	76	586	0	119	38	0	297	0
S	69	77	1	0	121	122	2	36	0	131	0	182	120	0	114	0	124	1	15	47
T	259	0	1	5	0	1	0	217	39	2	291	57	57	0	48	121	0	0	0	0
V	240	0	24	34	46	63	0	543	0	230	408	0	0	0	1	1	0	0	0	1
W	0	44	0	0	0	18	0	0	0	22	0	0	1	3	64	9	0	0	0	0
Y	0	187	18	0	43	1	116	1	0	5	0	23	0	1	0	29	0	1	0	0