Being a Physicist, I have started my research on Computational Molecular Biophysics in 1989. I earned by PhD degree for the thesis entitled, "Prediction of secondary structure and stability of globular and membrane proteins: surrounding hydrophobicity models" from Bharathidasan University, India.

I gained my first Post Doctoral experience on DNA bending and protein-DNA interactions at International Cente for Genetic Engineering and Biotechnology (ICGEB), Italy. I was involved in the development of thermodynamic databases for proteins and protein-nucleic acid interactions, stability of proteins upon mutations and computer simulation of protein-DNA interactions during my subsequent postdoc at The Institute of Physical and Chemical Research (RIKEN), Japan. Subsequently, I served as a Research Scientist and a Senior Research Scientist at Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Japan.

At present I am working as a Professor at the Department of Biotechnology, Indian Institute of Technology Madras, India. I am concentrating on the structural analysis and prediction of outer membrane proteins, prediction of solvent accessibility, protein folding rates, inter-residue interactions in protein folding, cation-pi interactions, protein-protein, protein-RNA and protein-DNA recognition, and thermodynamic databases. I have written a book on "Protein Bioinformatics: From Sequence to Function" and edited a book on "Recent Research Developments on Protein Folding, Stability and Design".