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20/04/2025

• Published an invited review “Protein structural bioinformatics: an overview”, M. Michael Gromiha* , F. Ridha and S. Selvaraj in Encyclopedia of Bioinformatics and Computational Biology.

11/04/2025

• We congratulate Fathima Ridha for receiving the Institute Research Award

10/04/2025

• Published an article "PRA-MutPred: Predicting the effect of point mutations in protein-RNA complexes using structural features", K. Harini, M. Sekijima and M. Michael Gromiha* in Journal of Chemical Information and Modeling.

01/04/2025

• Prof. Michael Gromiha delivered a Keynote talk at the “Weihenstephan Bioinformatics Symposium” at Technical University of Munich, Germany.

31/03/2025

• Published an article "P21-activated kinase 1 (PAK1) modulates therapeutic response to ionizing radiation in head and neck squamous cell carcinoma cells", S. Rajendran, R.P. Surabhi, A.S. Kumar, P. Gopinath, V. Kanakaveti, G. Shanmugasundaram, M. Michael Gromiha , S.K. Rayala and G. Venkatraman in Molecular Carcinogenesis.

27/03/2025

• Prof. Michael Gromiha delivered an invited talk at National Cancer Institute, Copenhagen, Denmark.

17/03/2025

• Published an article " Investigating local sequence-structural attributes of light chain variable domains (VLs) in amyloidosis", P. Rawat, R. Prabakaran, D. Sharma, V. Mandala, V. Greiff, S. Kumar, M Michael Gromiha in PROTEINS: Structure, Function and Bioinformatics

12/03/2025

• We welcome Mrs. H. M. Nisha to Protein Bioinformatics Lab as a Ph.D scholar.

01/03/2025

• We welcome Ms. S. Vaishnavi to Protein Bioinformatics Lab as a Ph.D scholar.

01/03/2025

• We congratulate Fathima Ridha on receiving the Best Flash Talk Award at the Horizons in Structural and Computational Biology (HSCB 2025) conference, held at IIT Hyderabad.

28/02/2025

• Fathima Ridha presented a flash talk and a poster on "Investigating binding affinity and mutational effects in membrane protein complexes: A computational perspective" at the Horizons in Structural and Computational Biology (HSCB 2025) conference, held at IIT Hyderabad

28/02/2025

• Prof. Michael Gromiha delivered a Keynote lecture at the “Horizons in structural and computational biology” at IIT Hyderabad.

25/02/2025

• Prof. Michael Gromiha delivered an invited talk at the "National Conference on “Drug Discovery 2025: Emerging Trends and Future Perspectives” at Jamia Millia Islamia, New Delhi

22/02/2025

• Published an article “ZFP-CanPred: Predicting the Effect of Mutations in Zinc-Finger Proteins in Cancers Using Protein Language Models”, A. Phogat, S.R. Krishnan, M. Pandey and M. Michael Gromiha* in Methods.

20/02/2025

• Dr. Suresh from Technical University of Denmark visited Protein Bioinformatics Lab.

18/02/2025

• Prof. Dmitrij Frishman visited Protein Bioinformatics Lab and delivered an invited talk on 18^th February 2025.

09/02/2025

• Conducted NPTEL workshop on WEKA: Exploring machine learning for healthcare - batch 3.

01/02/2025

• Published a review “Role of HSP90 in Type2 Diabetes mellitus and its association with Liver diseases.”, V. Nithyasree, P. Magdalene, P.K. Praveen Kumar, J. Preethi and M. Michael Gromiha in Molecular Biotechnology.

17/01/2025

• Prof. Michael Gromiha delivered a keynote lecture at the "15^th International Conference on Biosciences, Biochemistry and Bioinformatics", at Chulalongkorn University, Bangkok, Thailand.

08/01/2025

• We congratulate Dr. Divya Sharma for successfully defending her thesis on "Computational investigation of binding affinity, mutational effects and therapeutics of SARS-CoV-2 neutralizing antibodies".

05/01/2025

• We congratulate Sowmya for receiving the Research Excellence Award from IIT Madras.

01/01/2025

• Published a review "Protein-nucleic acid complexes: docking and binding affinity", M. Michael Gromiha and k. Harini in Current Opinion in structural Biology.

25/12/2024

• Published an article "MPA-MutPred: A novel strategy for accurately predicting the binding affinity change upon mutation in membrane protein complexes.", F. Ridha and M. Michael Gromiha* in Briefings in Bioinformatics.

19/12/2024

• Prof. Michael Gromiha delivered an invited talk at the “Faculty Development Program on "Computational Genomics: Theory and Application”, NIT Warangal.

17/12/2024

• Mr. Sankaran delivered an oral presentation at the TAC-MI International Forum 2024, Institute of Science Tokyo, Japan

17/12/2024

• Prof. M. Michael Gromiha delivered a Keynote lecture at the TAC-MI International Forum 2024, Institute of Science Tokyo, Japan.​​​

10/12/2024

• Prof. Michael Gromiha delivered a Keynote lecture at the “National Conference on Innovative Minds Illuminating Future Frontiers: a tribute to the 2024 Nobel prize in Chemistry”, Madras Christian College, Chennai.

08/12/2024

• Our paper "DeepPPAPredMut: deep ensemble method for predicting the binding affinity change in protein-protein complexes upon mutation."(R. Nikam, S. Jemimah and M. Michael Gromiha) has been covered as a Press release in more than 20 leading Newspapers.

05/12/2024

• Prof. Michael Gromiha delivered an invited guest lecture at the Physics Association Meeting, Christian College, Marthandam.

05/12/2024

• Published an article “Combinatorial Effects of 5-fluorouracil and Menadione on Wnt/β-catenin Pathway in Human Colorectal Cancer Cells”, V.P. Warrier, S. Venkatachalam, R. Sakthivel, M. Michael Gromiha , D. Karunagaran in Applied Biochemistry and Biotechnology.

29/11/2024

• Prof. Michael Gromiha delivered a Keynote lecture at the "8th International Conference on Computational Biology and Bioinformatics", Kyoto, Japan.

20/11/2024

• Published a book "Protein mutations: consequences on structure, functions and diseases". Edited by M. Michael Gromiha, World Scientific, Singapore

12/11/2024

• Prof. Michael Gromiha delivered an invited talk at Chuo University, Tokyo.

11/11/2024

• We congratulate Dr. Harini for successfully defending her thesis on "Computational resources for understanding and predicting the binding affinities of protein-nucleic acid complexes and their mutants".

05/11/2024

• Prof. Michael Gromiha delivered an invited talk at KL University, Vijayawada.

01/11/2024

• Published an article “Tracing ALS Degeneration: Insights from Spinal Cord and Cortex Transcriptomes”, N. P. Sneha, S.A.P. Dharshini, Y.-h. Taguchi and M. Michael Gromiha* in Genes.

24/10/2024

• Ramakrishna Reddy presented a poster on "Predicting the stability of membrane proteins using sequence and structural features" at the Asia & Pacific Bioinformatics Joint Conference (APBJC) 2024 held in Japan.

24/10/2024

• Fathima Ridha gave an oral talk on "Computational insights into binding affinity of membrane protein-protein complexes and mutational effects" at the Asia & Pacific Bioinformatics Joint Conference (APBJC) 2024 held in Japan.

23/10/2024

• Fathima Ridha presented a poster on "Novel computational method for predicting the mutational effects on the binding affinity of membrane protein protein complexes " at the Asia & Pacific Bioinformatics Joint Conference (APBJC) 2024 held in Japan.

18/10/2024

• Prof. Michael Gromiha delivered an invited talk at the Central University of Tamilnadu.

15/10/2024

• Published an article "DeepPPAPredMut: deep ensemble method for predicting the binding affinity change in protein-protein complexes upon mutation", R. Nikam, S. Jemimah and M. Michael Gromiha* in Bioinformatics.

09/10/2024

• Prof. Michael Gromiha delivered an invited talk at the "GNR Conference on Structural Biology and Drug Discovery", SRM institute of Science and Technology, Chennai, Oct 2024.

01/10/2024

• We welcome Ms. Vaishnavi as a Project Associate

19/09/2024

• Prof. Michael Gromiha delivered an invited talk at the National University of Singapore

16/09/2024

• We congratulate Fathima Ridha for receiving the travel fellowship from SERB to present at "1st Asia & Pacific Bioinformatics Joint Conference (APBJC 2024)", Japan.

10/09/2024

• Prof. Michael Gromiha delivered an invited talk at PSGR krishnammal College for Women, Coimbatore.

08/09/2024

• Conducted NPTEL workshop on WEKA: Exploring machine learning for healthcare - batch 2.

06/09/2024

• We welcome Ms. J. Afra to Protein Bioinformatics Lab as a Ph.D scholar.

05/09/2024

• Published a review "Structural and functional studies on HIV protease: mechanism of action, subtypes, inhibitors and drug resistance", S. Venkatachalam, S.R. Krishnan, Y. Sayed and M. Michael Gromiha in Methods in Molecular Biology

01/09/2024

• Prof. M. Michael Gromiha has been appointed as an Associate Editor of the journal, Bioinformatics and Biology Insights.

29/08/2024

• Prof. M. Michael Gromiha delivered an invited talk at the "Faculty Development Program", at Vellore Institute of Technology, Vellore.

28/08/2024

• Divya Sharma presented a poster on "Computational investigation of binding affinity of SARS-CoV-2 spike protein-neutralizing antibody complexes and their mutants" at 18th International Symposium of the Protein Society of Thailand (PST 2024) held at Bangkok, Thailand.

14/08/2024

• Prof. M. Michael Gromiha delivered an invited lecture at the University of Wiwatersrand, Johannesburg, South Africa.

14/08/2024

• Prof. Shoba Ranganathan from Macquarie University visited our lab on 14^th August and interacted with students.

09/08/2024

• ​Registrations for NPTEL workshop "WEKA: Exploring Machine Learning for Healthcare – Batch 2" are open. Kindly register using the following link. Click here to register. WEKA: Exploring Machine Learning for Healthcare – Batch 2. ​​

05/08/2024

• Dr. Kulandaisamy from Harvard Medical School, USA (Protein Bioinformatics Lab alumni) visited our lab on 5th August and interacted with students.

01/08/2024

• Published a review “The Role of HSP90 and TRAP1 Targets on Treatment in Hepatocellular Carcinoma”, P.K. Praveen Kumar, H. Sundar, K. Balakrishnan, S. Subramaniam, R. Hemalath, M. Kevin and M. Michael Gromiha in Molecular Biotechnology.

27/07/2024

• Prof. M. Michael Gromiha has been appointed as an Editorial Board Member of the journal, Methods (Elsevier).

11/07/2024

• Published an article "rAbDesFlow: A novel workflow for computational recombinant antibody design for healthcare engineering.", S.R. Krishnan, D. Sharma, Y. Nazeer, M.V. Bose, T. Rajkumar, G. Jayaraman, N. Madaboosi and M. Michael Gromiha in Antibody Therapeutics.

11/07/2024

• We congratulate Dr. Nela Pragathi Sneha for successfully defending her thesis on "Exploring neuron degeneration through transcriptome studies on Huntington’s disease and Amyotrophic lateral sclerosis".

07/06/2024

• Published an article "CarbDistMut: Database on neutral and disease-causing mutations in human carbohydrate-binding proteins", N.R. Siva Shanmugam, A. kulandaisamy, K. Veluraja and M. Michael Gromiha in Glycobiology.

29/05/2024

• Dr. Akila from Stanford University (Protein Bioinformatics Lab alumni) visited our lab on 29th May and delivered a talk.

15/05/2024

• Prof. M. Michael Gromiha has been recognized as an inaugural ScholarGPS Highly Ranked Scholar (topmost 0.01% in Bioinformatics).

09/05/2024

• Published an article "PRA-Pred: Structure-based prediction of protein-RNA binding affinity", K. Harini, M. Sekijima and M. Michael Gromiha In ternational Journal of Biological Macromolecules.

24/04/2024

• Our paper "Elucidating important structural features for the binding affinity of spike - SARS-CoV-2 neutralizing antibody complexes" has been recognized as a top cited paper in PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS.

19/04/2024

• Published an article "Sialic acid analogue as inhibitor for human coronavirus OC43-A study by molecular dynamics simulations.", J. J. Blessy, N.R. Siva Shanmugam, K. Veluraja and M. Michael Gromiha in Journal of Carbohydrate Chemistry.

07/04/2024

• Conducted NPTEL workshop on WEKA: Exploring machine learning for healthcare.

23/03/2024

• Prof. M. Michael Gromiha delivered an invited talk at the workshop on "Establishing and Sustaining Cloud Infrastructure for Informatics-based Healthcare”, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), India.

22/03/2024

• Prof. M. Michael Gromiha delivered an invited talk at Vellore Institute of Technology, Vellore, India.

20/03/2024

• We congratulate Pragathi Sneha for receiving the Women Leading IITM 2024 award.

15/03/2024

• Published an article "Mechanism of drug resistance in HIV-1 protease subtype C in the presence of Atazanavir", S.V. Sankaran, S.R. Krishnan, Y. Sayed and M. Michael Gromiha in Current Research in Structural Biology.

10/03/2024

• Prof. M. Michael Gromiha delivered an invited talk at KL University, Vijayawada, India.

08/03/2024

• Published an article "MPA-Pred: A machine learning approach for predicting the binding affinity of membrane protein-protein complexes", Fathima Ridha and M. Michael Gromiha in Proteins.

07/03/2024

• Published a review “Importance of inter-residue contacts for understanding protein folding and unfolding rates, remote homology and drug design”, Harihar, K.M. Saravanan, M. Michael Gromiha and S. Selvaraj ​ in Molecular Biotechnology.

28/02/2024

• Prof. M. Michael Gromiha delivered an invited talk at Chuo University, Tokyo, Japan.

22/02/2024

• Published an Editorial “From Code to Cure: The Impact of Artificial Intelligence in Biomedical Applications”, M. Michael Gromiha*, P. Preethi and Medha Pandey ​ in BioMedInformatics.

12/02/2024

• Published an article “ Predicting the immune escape of SARS-CoV-2 neutralizing antibodies upon mutation”, D. Sharma, P. Rawat, V. Greiff, V. Janakiraman and M. Michael Gromiha*​ in BBA: Molecular Basis of Diseaes.

07/02/2024

• We congratulate Dr. Rahul Nikam for successfully defending his thesis on "Predicting the binding affinity of protein-protein complexes and their mutants using deep learning​​​"​​.

01/02/2024

• Prof. M. Michael Gromiha delivered an invited talk at the “International Conference on Integrating Recent Innovations in Science and Technology: Shaping the Future”, Dhanalakshmi Srinivasan Engineering College, Perambalur.

26/01/2024

• We are conducting PBI Lab symposium on "Bio-molecular interactions: Applications to diseases" on 26th & 31st Jan 2024.​​ We thank Prof. Velmurugan for joining us as chief guest.

15/01/2024

• ​Prof. M. Michael Gromiha delivered an invited talk at Bioinformatics Institute, A*Star,​ Singapore.​​

01/01/2024

• ​Published an article “Reliable method for predicting the binding affinity of RNA-small molecule interactions using machine learning”, S.R. Krishnan, A. Roy and M. Michael Gromiha*​ in Briefings in Bioinformatics.​​

26/12/2023

• ​Published a letter to the Editor "Comment on “Thermodynamic database supports deciphering protein–nucleic acid interactions”, M. Michael Gromiha* and K. Harini in Trends in Biotechnology.​​​

20/12/2023

• ​Prof. M. Michael Gromiha delivered an invited talk at the Faculty Development Program on " Computer aided drug design and systems biology”, Holy cross college, Trichy.​​​

14/12/2023

• ​Published an article "MutBLESS: A tool to identify disease-prone sites in cancer using deep learning.", M. Pandey and M. Michael Gromiha* ​in Biochim. Biophys. Acta: Molecular Basis of Diseases.​​​

14/12/2023

• ​We congratulate Fathima for receiving the Good Oral Presentation Award at TAC-MI International Forum 2023, Tokyo Institute of Technology, Japan for her work on "Understanding the binding affinity of membrane protein-protein complexes: A computational approach".​​​

13/12/2023

• ​Prof. M. Michael Gromiha delivered a Keynote lecture at the TAC-MI International Forum 2023, Tokyo Institute of Technology, Japan.​​​

11/11/2023

• ​We congratulate Divya Sharma for receiving the travel fellowship from SERB for presenting the poster at GIW ISCB Asia 2023 conference held at​​​ Singapore from 18-21 November 2023.

30/11/2023

• ​We congratulate Harini for receiving the best oral presentation award (First prize) at the Indian Conference on Bioinformatics 2023 (InBix 2023), held at VIT Vellore.​​​

26/11/2023

• Fathima Ridha gave an oral talk on "Exploring the binding affinity and mutational implications in membrane protein-protein complexes: A computational approach" in the ISCB 2nd Asian Student Council Symposium (ASCS 2023).​​​

25/11/2023

• Harini K presented an oral talk on "Computational resources for understanding and predicting the binding affinity of protein-nucleic acid complexes" at the Indian Conference on Bioinformatics 2023 (InBix 2023), held at VIT Vellore.​​​

24/11/2023

• Divya Sharma presented a poster on "Computational approaches for understanding the binding affinity of SARS-CoV-2 spike protein-neutralizing antibody complexes and their mutants" at the GIW-ISCB Asia 2023 held at Novena, Singapore.​​​

23/11/2023

• Published an article "Deep learning-based method for predicting and classifying the binding affinity of protein-protein complexes.", R. Nikam; K, Yugandhar and M. Michael Gromiha* ​in Biochim. Biophys. Acta: Proteins and Proteomics.

22/11/2023

• Nela Pragathi Sneha presented a poster on "Understanding Huntington's disease transcriptome landscape using multi-omics approach" at the 22nd International Conference on Bioinformatics (InCoB 2023) held at Brisbane, Australia.​​​

21/11/2023

• We congratulate Dr. Medha Pandey for joining as a Post Doctoral Fellow at Harvard Medical School, Boston, USA.

20/11/2023

• We congratulate Pragathi Sneha​ for receiving the InCoB Travel Award.​​​

13/11/2023

• Prof. M. Michael Gromiha delivered a series of invited guest lectures at IISER Thiruvananthapuram.

08/11/2023

• ​We congratulate Medha Pandey​ for receiving the Institute Research Award.​​​

01/11/2023

• ​​Published an article "Investigating neuron degeneration in Huntington’s disease using RNA-seq based transcriptome study", N.P. Sneha, S.A.P. Dharshini, Y-h. Taguchi and M. Michael Gromiha* ​in Genes.

13/10/2023

• We congratulate Dr. Medha Pandey for successfully defending her thesis on "Analysis and development of machine learning models for driver mutations and disease-prone sites in cancer genomes​​"​​.

10/10/2023

• ​Prof. M. Michael Gromiha delivered an invited lecture at the "International Conference cum Workshop on Artificial intelligence solutions for pharmaceutical research and knowledge", NIPER, Punjab​.​​

08/10/2023

• ​Published an article "TMH Stab-pred: Predicting the stability of α-helical membrane proteins using sequence and structural features.", R. Reddy, A. Kulandaisamy and M. Michael Gromiha* ​in Methods.​​

06/10/2023

• ​Prof. Chandra Verma from Bioinformatics Institute, A*Star, Singapore, visited our lab on 6th Oct 2023.​​

27/09/2023

• Published a review "Bioinformatics approaches for understanding the binding affinity of protein-nucleic acid complexes", K. Harini, M. Sekijima and M. Michael Gromiha*​​ ​in Methods in Molecular Biology.​

21/09/2023

• We welcome Ms. Preethi P. to Protein Bioinformatics Lab as a Ph.D scholar.​

10/09/2023

• Conducted NPTEL workshop on Applications of machine learning techniques in biology using Weka. ​​

07/09/2023

• Published an article "TMKit: a Python interface for computational analysis of transmembrane proteins.", J. Sun, A. Kulandaisamy, J. Ru, M. Michael Gromiha*, A.P. Cribbs* ​ in Briefings in Bioinformatics.

03/09/2023

• Prof. M. Michael Gromiha delivered an invited lecture on the 2nd Anniversary of Prof. N. Srinivasan at IISc, Bangalore.

18/08/2023

• ​Registrations for NPTEL workshop "Applications of machine learning techniques in biology using Weka" are open. Kindly register using the following link. Click here to register. Applications of machine learning techniques in biology using Weka. ​​

09/08/2023

• Published an Editorial "Protein recognition and associated diseases", M. Michael Gromiha*, P. Kundrotas, M.A. Marti, Č. Venclovas and M. Li​​ ​in Frontiers in Bioinformatics.

31/07/2023

• Harini K presented a poster on "Computational resources for understanding and predicting the binding affinity of protein-nucleic acid complexes" at "31st conference on Annual Intelligent Systems For Molecular Biology and the 22nd Annual European Conference on Computational Biology (ISMB/ECCB-2023)" held at Lyon, France.

31/07/2023

• Fathima Ridha presented a poster on " Computational resources for understanding the binding affinity of membrane protein-protein complexes and their mutants " at "31st conference on Annual Intelligent Systems For Molecular Biology and the 22nd Annual European Conference on Computational Biology (ISMB/ECCB-2023)" held at Lyon, France.

31/07/2023

• Fathima Ridha gave an oral talk on " Computational resources for understanding the binding affinity of membrane protein-protein complexes and their mutants " in the 19th ISCB Student Council Symposium (SCS 2023) at the ISMB/ECCB-2023 conference held at Lyon, France.

06/07/2023

• Published a review "Computational approaches for identifying disease-causing mutations in proteins", M. Pandey, S.K. Shah, and M. Michael Gromiha*​​ ​in Advances in Protein Chemistry and Structural Biology.

01/07/2023

• Prof. M. Michael Gromiha has been elected as a Fellow of Chennai Academy of Sciences.

15/06/2023

• Published an article "R-SIM: A database of binding affinities for RNA-small molecule interactions", S.R. Krishnan, A. Roy and M. Michael Gromiha*​​ ​in Journal of Molecular Biology.

02/06/2023

• Research scholar Pragathi Sneha presented a poster on "Exploring neuron declension in Huntington’s disease – RNA based transcriptome study" at "Symposium on Big Data Algorithms for Biology 2023" held at IISc Bengaluru, India

02/06/2023

• Research scholar Divya Sharma presented a poster on "In silico evaluation of the impact of Omicron variant of concern sublineages on the sensitivity of RT-qPCR assays for SARS-CoV-2 detection using whole genome sequencing" at "Symposium on Big Data Algorithms for Biology 2023" held at IISc Bengaluru, India

23/05/2023

• Prof. M. Michael Gromiha delivered an invited lecture at the Institute of Mathematical Sciences, Chennai.​

20/05/2023

• Published an article "DeepBSRPred: Deep learning-based Binding Site Residue Prediction for proteins", R. Nikam, K. Yugandhar and M. Michael Gromiha​*​​ ​in Amino Acids.​

09/05/2023

• Prof. M. Michael Gromiha delivered an invited lecture at the Faculty Development Program on "Development of therapeutics using Bioinformatics: Recent trends and strategies”, NIT Warangal.​

06/05/2023

• Published an article "PDA-Pred: Predicting the binding affinity of protein-DNA complexes using machine learning techniques and structural features", K. Harini, D. Kihara, M. Michael Gromiha*​​ ​in Methods.​

03/05/2023

• Our paper "Identification of potential driver mutations in glioblastoma using machine learning" ​(M. Pandey, P. Anoosha, D. Yesudhas and M. Michael Gromiha​) has been covered as a Press release in more than 50 leading Newspapers.​

14/04/2023

• Published an article "CoDe: A web-based tool for Codon Deoptimization.", D. Sharma, T.L. Baas, A. Nogales, L. Martinez-Sobrido and M. Michael Gromiha*​ ​in Bioinformatics Advances.​

06/04/2023

• We welcome S. Lekshmi to Protein Bioinformatics Lab as a Ph.D scholar.​

05/04/2023

• Prof. M. Michael Gromiha delivered an invited lecture at Vel-Tech High-Tech Engineering College, Chennai.​

01/04/2023

• Published an article "Understanding drug resistance of wild-type and L38HL insertion mutant of HIV-1 C protease to saquinavir", S.V. Sankaran, N. Murlidharan, S. Krishnan, C. Ramakrishnan, M. Setshedi, R. Pandian, D. Barh, S. Tiwari, V. Azevedo, Y. Sayed and M. Michael Gromiha*​ ​in Genes.​

25/03/2023

• Prof. M. Michael Gromiha delivered an invited talk at the Symposium on “Innovations in Artificial Intelligence in Biotechnology and Healthcare”, Jaipur National University, Jaipur.​

21/03/2023

• Prof. M. Michael Gromiha delivered an invited talk at the “National Conference in Recent Trends in Biotechnology and its applications”, Vels Institute of Science, Technology and Advanced Studies, Chennai.

18/03/2023

• Published a book chapter "Identification of Cancer Hotspot Residues and Driver Mutations Using Machine Learning", M. Pandey, P. Anoosha, D. Yesudhas and M Michael Gromiha*​​ ​in “Machine Learning in Bioinformatics of Protein Sequences: Algorithms, Databases and Resources for Modern Protein Bioinformatics” (Ed. L. Kurgan), World Scientific, Singapore​.

15/03/2023

• Prof. M. Michael Gromiha delivered an invited lecture at University of Witwatersrand, Johannesburg, South Africa​.

14/03/2023

• Published an article "Machine learning in computational modelling of membrane protein sequences and structures: from methodologies to applications", J. Sun, A. Kulandaisamy, K. Hu, M. Michael Gromiha* and Y. Zhang*​​ ​in Computational and Structural Biotechnology Journal.

13/03/2023

• We congratulate Suraj Kumar Shah for receiving the Prime Minister's Research Fellowship.

08/03/2023

• We congratulate Medha Pandey for receiving the Women Leading IITM 2023 award​.

06/03/2023

• Published an article "AutoPLP: A padlock probe design pipeline for zoonotic pathogens", S.R. Krishnan, R.R.G. Soares, N. Madaboosi and M Michael Gromiha*​ ​in ACS Infectious Diseases.

05/03/2023

• Conducted NPTEL workshop on Applications of machine learning techniques in biology using Weka. ​​

01/03/2023

• Our paper "Why are ACE2 binding coronavirus strains SARS-CoV/SARS-CoV-2 wild and NL63 mild?" ​has been recognized as a top cited paper in PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS.

26/02/2023

• Published an article "Alz-Disc: A tool to discriminate disease-causing and neutral mutations in Alzheimer's disease.", A. Kulandaisamy, S.A.P. Dharshini, M. Michael Gromiha* ​in Combinatorial Chemistry & High Throughput Screening.

23/02/2023

• We congratulate Dr. N.R. Siva Shanmugam for successfully defending his thesis on "Understanding the relationship between amino acid properties and binding affinity of protein-carbohydrate complexes: Analysis and prediction​​"​​.

23/02/2023

• ​Registrations for NPTEL workshop "Applications of machine learning techniques in biology using Weka" are open. Kindly register using the following link. Click here to register ​​

21/02/2023

• Prof. M. Michael Gromiha delivered an Inaugural address at a National Workshop on “Recent Trends in Computer-Aided Drug Discovery”, Loyola College, Chennai.

20/02/2023

• Published an article "Structure Based Drug Designing Approaches in SARS-CoV-2 Spike Inhibitor Design", A. Shanmugam, A. Venkattappan, M. Michael Gromiha* ​in Current Topics in Medicinal Chemistry.

11/02/2023

• Published an article "In silico evaluation of the impact of Omicron variant of concern sublineage BA.4 and BA.5 on the sensitivity of RT-qPCR assays for SARS-CoV-2 detection using whole genome sequencing", D. Sharma, K.I. Notarte, R.A. Fernandez, G. Lippi, M. Michael Gromiha*, B.M. Henry* ​ ​ ​in Journal of Medical Virology.

09/02/2023

• Prof. Michael Gromiha and Prof. Taguchi are editing a special issue on "Proteins and Genes Bioinformatics: Analysis, Algorithms and Applications" to Genes. Interested researchers are invited to submit their manuscripts. Details are available at this link

17/01/2023

• Published an article "Exploring plausible therapeutic targets for Alzheimer's disease using multi-omics approach, machine learning and docking", S. A. P. Dharshini, N.P. Sneha, D. Yesudhas, A. Kulandaisamy, U. Rangaswamy, A. Shanmugam, Y-h. Taguchi and M. Michael Gromiha* ​in Current Topics in Medicinal Chemistry.

12/01/2023

• Prof. M. Michael Gromiha delivered an invited lecture at Chuo University, Tokyo, Japan.

10/01/2023

• Published an article "Integrative Meta-Analysis of Huntington’s Disease Transcriptome Landscape", N.P. Sneha, S.A.P. Dharshini, Y-h. Taguchi and M. Michael Gromiha* in Genes.

08/01/2023

• Prof. M. Michael Gromiha delivered an invited talk at the Sungkyun Biotech International Conference on “A Recent Trend in Biotech Research”, Seoul, Korea.

01/01/2023

• Published an article "MPAD: A database for binding affinity of membrane protein-protein complexes and their mutants.", F. Ridha, A. Kulandaisamy​ and M. Michael Gromiha* in Journal of Molecular Biology.

21/12/2022

• Prof. M. Michael Gromiha delivered a Keynote lecture at the TAC-MI International Forum 2022, Tokyo Institute of Technology, Japan.

16/12/2022

• Published an article "Identification of potential driver mutations in glioblastoma using machine learning", M. Pandey, P. Anoosha, D. Yesudhas and M. Michael Gromiha* ​ ​in Briefings in Bioinformatics.

13/12/2022

• Prof. Satoshi Murakami from Tokyo Institute of Technology, Japan visited our lab on 13th Dec 2022.​​

13/12/2022

• ​We congratulate Divya Sharma​ for receiving the Social Impact Award at Tokyo Tech Academy for Convergence of Materials and Informatics (TAC-MI).​​

01/12/2022

• Prof. M. Michael Gromiha delivered an invited talk at the 2nd International conference on "Recent trends in structural bioinformatics and computer aided drug design" at Alagappa University, Karaikudi.

25/11/2022

• We welcome Mr. Suraj and Mr. Amit as PhD students.​

24/11/2022

• Published an article "Ab-CoV: a curated database for binding affinity and neutralization profiles of coronavirus related antibodies", P. Rawat, D. Sharma, R. Prabakaran, F. Ridha, M. Mugdha, V. Janakiraman, M. Michael Gromiha* ​ ​in Bioinformatics.

14/11/2022

• Prof. M. Michael Gromiha delivered a Plenary lecture at the National Conference on “Technology & Innovation in Healthcare (NCTIH22)", Vinayaka Missions Kirupananda Variyar Medical College and Hospital, Salem.

10/11/2022

• Published an article "Novel BH4-BCL-2 domain antagonists induce BCL-2 mediated apoptosis in triple negative breast cancer", V. Kanakaveti, R. Sakthivel, R. Kanumari, B. Vaishnavi, R. Saravanan, I. Ezhil, R. Pitani, G. Venkatraman, S.K. Rayala, M. Michael Gromiha* ​ ​in Cancers.

31/10/2022

• Prof. M. Michael Gromiha delivered a Valedictory address at the National Conference on “Role of Artificial Intelligence in Molecular Medicine” at Alpha Arts and Science College, Chennai.

26/10/2022

• Published a review "Computational approaches for investigating disease-causing mutations in membrane proteins: database development, analysis and prediction", A. Kulandaisamy, F. Ridha, D. Frishman and M. Michael Gromiha​ ​in Current Topics in Medicinal Chemistry.

17/10/2022

• Prof. M. Michael Gromiha has been elected as a Fellow of Indian National Science Academy (INSA).

08/10/2022

• Prof. M. Michael Gromiha delivered a Plenary lecture at the “International Symposium on 'Recent Trends in Macromolecular Structure and Function, Marine Biotechnology and Bioinformatics ", AMET University, Chennai.​ ​​

06/10/2022

• Published an article "Understanding the mutational frequency in SARS-CoV-2 proteome using structural features", P. Rawat, D. Sharma, M. Pandey, R. Prabakaran, M. Michael Gromiha​ ​in Computers in Biology and Medincine. ​​

01/10/2022

• Prof. M. Michael Gromiha delivered an Invited lecture at National University of Singapore.​​

19/09/2022

• We welcome Mr. Sankaran as a Project Associate.​

03/09/2022

• Conducted NPTEL workshop on Applications of machine learning techniques in biology using Weka. ​​

22/08/2022

• Published an article "Ad interim recommendations for diagnosing SARS-CoV-2 infection by the IFCC SARS-CoV-2 Variants Working Group", G. Lippi, J. Favresse, M. Michael Gromiha, J. SoRelle, EPH. Yap, M. Plebani, BM. Henry ​in Clinical Chemistry Laboratory Medincine.​​

01/08/2022

• Registrations closed for NPTEL workshop on Applications of machine learning techniques in biology using Weka. ​​

16/07/2022

• Prof. M. Michael Gromiha delivered an Invited talk at the "Teachers’ Training Workshop" jointly organized by IISER Thiruvananthapuram and the Department of Collegiate Education, Govt. of Kerala.​​

1/7/2022

• ​Published an article "PCA-MutPred: Prediction of binding free energy change upon missense mutation in protein-carbohydrate complexes", N.R. Siva Shanmugam, K. Veluraja and M. Michael Gromiha ​ in Journal of Molecular Biology. ​​

22/06/2022

• ​Prof. M. Michael Gromiha delivered an Invited lecture at Purdue University, USA.​​

15/06/2022

• ​We congratulate Dr. Prabakaran for joining as a Post Doctoral Fellow at Rutgers University, USA.​​

05/06/2022

• Published an article "Tumor heterogeneity and molecular characteristics of glioblastoma revealed by single-cell RNA-seq data analysis..", D. Yesudhas, S.A.P. Dharshini, Y-h. Taguchi and M. Michael Gromiha ​ in Genes​​.​​

26/05/2022

• Prof. M. Michael Gromiha delivered a series of lectures at the Faculty Development Program on “Basics of Bioinformatics” organized by Anna University, Trichy and NIT, Warangal​​.​​

13/05/2022

• ​Published an article "Evaluation of in silico tools for the prediction of protein and peptide aggregation on diverse datasets.", R. Prabakaran, P. Rawat, S. Kumar and M. Michael Gromiha ​ in Briefings in Bioinformatics..​​

01/05/2022

• ​We congratulate Siva Shanmugam​ for receiving the Institute Research Award.​​

25/04/2022

• ​We congratulate Dr. Akila for joining as a Post Doctoral Fellow at Stanford University, USA.​​

23/04/2022

• ​Prof. M. Michael Gromiha delivered an Invited talk at the National conference on "Recent advances in life sciences towards health care" at JSS Academy of Higher Education and Research, Ooty.​​

22/04/2022

• ​Prof. Chandra Verma from Bioinformatics Institute, A*Star, Singapore, visited our lab on 22nd April 2022.​​

20/04/2022

• We congratulate Dr. R. Prabakaran for successfully defending his thesis on "Sequence and structural studies of aggregation prone regions in proteins: development of a prediction method and large-scale analysis​"​​.​​

11/04/2022

• Published an article "Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein", R.A. Fernandez, M.T. Quimque, K.I. Notarted, J.A. Manzanoa, D.Y. Pilapil, V.N. de Leon, J.J.S. Josea, O.Villalobosf, N.H. Muralidharan, M. Michael Gromiha, S. Brogi and A.P.G. Macabeoa ​in Journal of Biomolecular Structure and Dynamics.​​

24/03/2022

• Prof. M. Michael Gromiha​ received the ASC-Masila Vijaya Award for Excellence in Scientific Research and Publications from The Academy of Sciences, Chennai.​​

09/03/2022

• Prof. M. Michael Gromiha delivered an Inaugural address at the Workshop on "Next Generation Sequencing Technologies" at Vels University, Chennai.​​

07/03/2022

• We welcome Dr. Sudha Govindarajan as a DBT-RA Fellow​​.

02/03/2022

• Published a Letter to the Editor "Srinivasan (1962-2021) in Bioinformatics and beyond", M. Michael Gromiha, C. Orengo, R. Sowdhamini and J. Thornton ​ in Bioinformatics.

28/2/2022

• Prof. M. Michael Gromiha delivered an Invited talk at the National conference on "Prevalent and Prospective paradigms in Machine learning for applications in Biology" at Nirmala College for Women, Coimbatore.

21/2/2022

• ​Published an article "Elucidating important structural features for the binding affinity of spike - SARS-CoV-2 neutralizing antibody complexes", D. Sharma, P. Rawat, V. Janakiraman and M. Michael Gromiha* ​ ​in PROTEINS: Structure, Function and Bioinformatics.

10/2/2022

• ​Published an article "Illustrative tutorials for ProThermDB: Thermodynamic database for proteins and mutants", A. Kulandaisamy, R. Nikam, K. Harini, D. Sharma and M. Michael Gromiha* ​ ​in Current Protocols

26/1/2022

• ​Published an article "A novel hybrid SEIQR model incorporating the effect of quarantine and lockdown regulations for COVID-19.", R. Prabakaran, S. Jemimah, P. Rawat, D. Sharma and M. Michael Gromiha* ​ in Scientific Reports

24/01/2022

• Prof. M. Michael Gromiha delivered a keynote lecture at the International Forum for Tokyo Tech Academy for Convergence of Materials and Informatics (TAC-MI) on “Bioinformatics: concepts and applications” at Tokyo Institute of Technology, Japan.​

18/01/2022

• We welcome Dr. Praveen Kumar as a SERB-TARE Fellow​​.​

01/01/2022

• Published an article "ProNAB: Database for binding affinities of protein-nucleic acid complexes and their mutants.", K. Harini, A. Srivastava, A. Kulandaisamy​ and M. Michael Gromiha ​ in Nucleic Acids Research.

10/12/2021

• Published an article "Effect of Charged Mutation on Aggregation of a Pentapeptide: Insights from Molecular Dynamics Simulations.", R. Prabakaran, P. Rawat, N. Yasuo, M. Sekijima, S. Kumar and M. Michael Gromiha ​ in PROTEINS: Structure, Function and Bioinformatics.

30/11/2021

• Prof. M. Michael Gromiha delivered a series of lectures at the Faculty Development Program on “Advanced Bioinformatics” organized by Anna University, Trichy and NIT, Warangal​​.​

24/11/2021

• Prof. M. Michael Gromiha delivered a​n Invited talk at the AICTE Training and Learning on "Computer Genomics Tools for Next Generation Sequencing and Biomedical Data Analysis" at Bharathiar University, Coimbatore.​

17/11/2021

• Published an article "PPAR-responsive elements (PPREs) enriched with Alu repeats revealed a descriptive contribution to PPARγ- DNMT1 interactions in the genome", A. Sharma, F. Tobar-Tosse, T. C. Dakal, H. Liu, A. Biswas, A. Menon, P. Anoosha, P. Katsonis, O. Lichtarge, M. Michael Gromiha , M. Ludwig, F.G. Holz, K.U. Löffler, M.C. Herwig-Carl ​ in Cancers.

3/11/2021

• Published an article "Exploring the sequence features determining amyloidosis in human antibody light chains", P. Rawat, R. Prabakaran, S. Kumar and M. Michael Gromiha* ​in ​Scientific Reports.

30/10/2021

• Prof. M. Michael Gromiha is listed as one of the topmost 0.5% of researchers in Bioinformatics, Biophysics and overall rank based on standardised citation metrics.

29/10/2021

• Our ​article –“AbsoluRATE: An in-silico method to predict the aggregation kinetics of native proteins” published in BBA – Proteins and Proteomics (P. Rawat, R. Prabakaran, S. Kumar and M. Michael Gromiha) has been selected to be featured in the latest BBA Collection “Artificial Intelligence for biochemistry and molecular biology: AI is learning to help”. It is curated by the BBA in-house Scientific Editors, highlight articles published across all BBA journals and cover topics of broad interest.

27/10/2021

• We congratulate Ramakrishna Reddy for receiving the Prime Minister's Research Fellowship.

25/10/2021

• We congratulate Dr. Puneet Rawat for joining as a Post Doctoral Fellow at University of Oslo, Norway.

23/10/2021

• We congratulate Divya Sharma and Fathima Ridha for receiving the Prime Minister's Research Fellowship.

19/10/2021

• Prof. M. Michael Gromiha delivered a​n Invited talk at “Health Informatics Summit” at IIIT Delhi.

18/10/2021

• We congratulate Dr. Vishnupriya Kanakaveti for joining as a Post Doctoral Fellow at Stanford University, USA.

11/10/2021

• We welcome Ramakrishna Reddy to Protein Bioinformatics Lab as a Ph.D scholar.

03/10/2021

• We congratulate Harini for receiving the Overseas Visiting Doctoral Fellowship (OVDF) at Purdue University from Science and Engineering Research Board.

27/09/2021

• Published an article "Investigations on the binding specificity of β-galactoside analogues with human galectin-1 using molecular dynamics simulations", J.J. Blessy, N.R.S. Shanmugam, K. Veluraja and M. Michael Gromiha* ​in ​J. Biomol. Struct. Dyn.

20/09/2021

• Prof. M. Michael Gromiha has been appointed as an Associate Editor in Bioinformatics Advances​.

10/09/2021

• Published an article "AbsoluRATE: An in-silico method to predict the aggregation kinetics of native proteins", P. Rawat, R. Prabakaran, S. Kumar and M. Michael Gromiha* ​in Biophys. Biochim. Acta - Proteins and Proteomics.

28/08/2021

• Published an article "Tackling Covid-19 using disordered-to-order transition of residues in the spike protein upon ACE2 binding", D. Yesudhas, A. Srivastava, M. Sekijima, M. Michael Gromiha* ​in PROTEINS: Structure, Function and Bioinformatics​.

23/08/2021

• Prof. M. Michael Gromiha has been appointed as an Associate Editor in Frontiers in Bioinformatics​.

12/08/2021

• Prof. M. Michael Gromiha delivered a series of lectures on “Basics and Applications of Bioinformatics” at IIT Dhanbad.

07/08/2021

• We welcome Ms. Sowmya R K on joining the lab as an external PhD scholar.

01/08/2021

• Published an article "Exploring antibody repurposing for COVID-19: Beyond presumed roles of therapeutic antibodies", P. Rawat, D. Sharma, A. Srivastava, V. Janakiraman and M. Michael Gromiha* ​in Scientific Reports.

28/07/2021

• We congratulate Dr. Ambuj Srivastava for joining as a Post Doctoral Fellow at University of California San Diego, USA.

16/07/2021

• We congratulate Dr. A. Kulandaisamy for receiving the Best Thesis Award.

1/07/2021

• Published an article "Understanding disorder-to-order transitions in protein–RNA complexes using molecular dynamics simulations", A. Srivastava, D. Yesudhas, S. Ahmad​ and M. Michael Gromiha* ​in Journal of Biomolecular Structure and Dynamics.

22/06/2021

• Prof. M. Michael Gromiha delivered a series of lectures at the Faculty Development Program on “Basics of Bioinformatics” organized by Anna University, Trichy and NIT, Warangal​​.

16/06/2021

• We congratulate Dr. Vishnupriya Kanakaveti for successfully defending her thesis on "Targeted Inhibition Of Bcl-2 Proteins: A Structural and Molecular Approach"​​.

11/06/2021

• We congratulate Dr. A. Kulandaisamy for receiving the Institute Research Award.

01/06/2021

• Published a review "Protein Aggregation: In silico Algorithms and Applications.", R. Prabakaran, P. Rawat, A. M, Thangakani, S. Kumar ​and M. Michael Gromiha* ​ in Biophysical Reviews.

24/05/2021

• We congratulate Dr. A. Kulandaisamy for joining as a Post Doctoral Fellow at Harvard Medical School, Boston, USA.

13/05/2021

• Prof. M. Michael Gromiha delivered a​ Plenary lecture at the Workshop on “Advances in Bioinformatics” at NIT, Warangal. ​​

08/05/2021

• Published an article "Deciphering the role of residues involved in disorder-to-order transition regions in archaeal tRNA methyltransferase 5", A. Srivastava, D. Yesudhas, S. Ahmad and M. Michael Gromiha* ​in Genes.

03/05/2021

• We congratulate Dr. Ambuj Srivastava for successfully defending his thesis on "Influence of intrinsically disordered regions for understanding the recognition of protein-RNA complexes". ​​

11/04/2021

• Published an article "Exploring common therapeutic targets for neurodegenerative disorders using transcriptome study", S. Akila Parvathy Dharshini, S. Jemimah, Y-h. Taguchi​ and M. Michael Gromiha* ​ in Frontiers in Genetics. ​​

24/03/2021

• Published an article "COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics", D. Yesudhas, A. Srivastava and M. Michael Gromiha* ​ in Infection. ​​

12/03/2021

• Published an article "Predicting potential residues associated with lung cancer using deep neural networks.", M. Pandey and M. Michael Gromiha* ​ in Mutation Research. ​​

08/03/2021

• We congratulate Dr. Akila for successfully defending her thesis on "Exploring the selective vulnerability in neurodegenerative disorders using transcriptome analysis"​​. ​​

01/03/2021

• We congratulate Dr. Kulandaisamy for successfully defending his thesis on "Development of Databases and Prediction Algorithms For Understanding the Consequences of Mutations on Membrane Protein Stability and Diseases"​​. ​​

26/02/2021

• Published an article "Mutations in transmembrane proteins: diseases, evolutionary insights and prediction", J. Zaucha, M. Heinzinger, A. Kulandaisamy, E. Kataka, Ó.L. Salvádor, P. Popov, B. Rost, M. Michael Gromiha, B.S. Zhorov and D. Frishman in Briefings in Bioinformatics. ​​

19/02/2021

• Prof. M. Michael Gromiha delivered an​ Invited talk at the Skill Development Certificate Course on “Advances in Data-Driven Statistical Applications and Computational Techniques” at Bharathiar University, Coimbatore. ​​

18/02/2021

• Prof. M. Michael Gromiha delivered an​ Invited talk at the 9th Tokyo Tech International symposium on “Life Science and Technology” at Tokyo Institute of Technology, Japan. ​​

06/02/2021

• Published an article "Why are ACE2 binding coronavirus strains SARS-CoV/SARS-CoV-2 wild and NL63 mild?", P. Rawat, S. Jemimah, P.K. Ponnuswamy and M. Michael Gromiha in PROTEINS: Structure, Function and Bioinformatics. ​​

15/01/2021

• Published an article "Identification of Transcription Factors, Biological Pathways, and Diseases as Mediated by N6-methyladenosine​ using Tensor Decomposition-Based Unsupervised Feature Extraction", Y-h. Taguchi, S.A.P. Dharshini and M. Michael Gromiha in Applied Sciences ​​

01/01/2021

• Published an article "ANuPP: A versatile tool to predict aggregation nucleating regions in peptides and proteins", R. Prabakaran, P. Rawat, S. Kumar and M. Michael Gromiha* in Journal of Molecular Biology. ​​

28/12/2020

• We congratulate Dr. Puneet Rawat for successfully defending his thesis on "Computational approaches for understanding the aggregation kinetics of proteins and mutants"​​. ​​

25/12/2020

• Published an article "Prediction of protein-carbohydrate complex binding affinity using structural features", N.R.S. Shanmugam, J. Blessy, K. Veluraja and M. Michael Gromiha* in Briefings in Bioinformatics. ​​

18/12/2020

• Prof. M. Michael Gromiha delivered an invited talk at the faculty development program on "Current Trends in Life Sciences" at Vellore Institute of Technology ​​

9/12/2020

• Published an article "ProThermDB: Thermodynamic database for proteins and mutants revisited after 15 years.", R. Nikam, A. Kulandaisamy, K. Harini, D. Sharma and M. Michael Gromiha* in Nucleic Acids Research.

17/11/2020

• Published an article "Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19", D. Barh, S. Tiwari, M.E. Weener, V. Azevedo, A. Góes-Neto, M. Michael Gromiha and P. Ghosh in Computers in Biology and Medicine.

09/11/2020

• We welcome Fathima as a Ph.D scholar.​

4/11/2020

• Prof. M. Michael Gromiha is ranked as the best scientist (No 1) in Bioinformatics from India based on citations/publications. The survey was done by researchers in Stanford University.

20/10/2020

• Published an article "MPTherm-pred: Analysis and prediction of thermal stability changes upon mutations in transmembrane proteins", A. Kulandaisamy, Jan Zaucha, Dmitrij Frishman​ and M. Michael Gromiha in Journal of Molecular Biology.

8/10/2020

• Published an article "Predicting the effect of variants associated with Alzheimer’s disease using machine learning.", U. Rangaswamy, S.A.P. Dharshini, D. Yesudhas1 and M. Michael Gromiha in Computers in Biology and Medicine

27/9/2020

• Published a review "Therapeutic targets and computational approaches on drug development for COVID-19.", A. Shanmugam, N. Muralidharan, D. Velmurugan and M. Michael Gromiha* ​ in Current Topics in Medicinal Chemistry

10/9/2020

• We congratulate Uday for getting PhD admission at SISSA, Italy.

20/08/2020

• Published an article "New insights into the stereospecific reduction by an (S) specific carbonyl reductase from Candida parapsilosis ATCC 7330: Experimental and QM/MM studies", S. Sudhakara, C. Ramakrishnan, M. Michael Gromiha and A. Chadha in Catalysis Science & Technology

03/08/2020

• We congratulate Dr. Sherlyn Jemimah for successfully defending her thesis on "Binding free energy changes in mutant protein-protein complexes: database development, prediction and analysis of disease-causing mutations"​​.

25/07/2020

• Published an article "Insights into changes in binding affinity caused by disease mutations in protein-protein complexes", S. Jemimah and M. Michael Gromiha* in Computers in Biology and Medicine.

11/07/2020

• We congratulate Sherlyn Jemimah for receiving Institute Research Award 2019-2020.

24/6/2020

• Prof. M. Michael Gromiha delivered an invited talk at the “International Webinar Series” on “Advances in Supramolecular and Biomolecular Research”, SSN College of Engineering, Chennai.

20/06/2020

• Published an article "MPTherm: Database for Membrane Protein Thermodynamics for understanding folding and stability". A. Kulandaisamy, R. Sakthivel and M. Michael Gromiha in Briefings in Bioinformatics.

08/06/2020

• Prof. M. Michael Gromiha delivered an inaugural address at the Virtual Workshop on "Protein Bioinformatics", organized by Kalasalingam Academy of Research and Education

30/05/2020

• We congratulate Sherlyn Jemimah for submitting her Ph.D thesis on "Binding free energy changes in mutant protein-protein complexes: database development, prediction and analysis of disease-causing mutations"​​ to IIT Madras.

23/05/2020

• Published an article "Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19". N. Muralidharan, R. Sakthivel, D. Velmurugan and M. Michael Gromiha in Journal of Biomolecular Structure and Dynamics

01/05/2020

• Published a book "Protein interactions: computational methods, analysis and applications". Edited by M. Michael Gromiha, World Scientific, Singapore.
• Published a book chapter "Binding affinity of protein-protein complexes: experimental techniques, databases and computational methods", S. Jemimah, K. Yugandhar and M. Michael Gromiha in “Protein interactions: computational methods, analysis and applications”, (Ed. M.M. Gromiha), World Scientific, Singapore, pp 87-108.
• Published a book chapter "Computational approaches for understanding the recognition mechanism of protein–nucleic acid complexes", A. Srivastava, D. Yesudhas, A. Kulandaisamy, N. Muralidharan, C. Ramakrishnan, R. Nagarajan and M. Michael Gromiha in “Protein interactions: computational methods, analysis and applications”, (Ed. M.M. Gromiha), World Scientific, Singapore, pp 169-216.​
• Published a book chapter "Prediction of nucleic acid binding proteins and their binding sites", D. Yesudhas, A. Srivastava, N. Muralidharan, A. Kulandaisamy, R. Nagarajan and M. Michael Gromiha in “Protein interactions: computational methods, analysis and applications”, (Ed. M.M. Gromiha), World Scientific, Singapore, pp 217-242.​
• Published a book chapter "Protein-carbohydrate complexes: binding site analysis, prediction, binding affinity and molecular dynamics simulations", K. Veluraja, N. R. Siva Shanmugam, J. Jino Blessy, R. A. Jeyaram, B. Lalithamaheswari and M. Michael Gromiha in “Protein interactions: computational methods, analysis and applications”, (Ed. M.M. Gromiha), World Scientific, Singapore, pp 299-332.​
• Published a book chapter "Quantitative structure-activity relationship in ligand-based drug design: concepts and applications", V. Kanakaveti, P. Anoosha, R. Sakthivel, S.K. Rayala and and M. Michael Gromiha in “Protein interactions: computational methods, analysis and applications”, (Ed. M.M. Gromiha), World Scientific, Singapore, pp 333-349.​

19/04/2020

• Published an article "ProCaff: protein-carbohydrate complex binding affinity database". Siva Shanmugam, J. Blessy, K. Veluraja and M. Michael Gromiha in Bioinformatics

11/04/2020

• Published an article "Neurodegenerative diseases - Is metabolic deficiency the root cause?". V.R. Muddapu, S.A.P. Dharshini, V. Srinivasa Chakravarthy and M. Michael Gromiha in Frontiers in Neuroscience.

30/03/2020

• Published an article " Identification of potential inhibitors for targets involved in dengue fever. A. Shanmugam, C. Ramakrishnan, D. Velmurugan and M. Michael Gromiha in Current Topics in Medicinal Chemistry.

10/03/2020

• We congratulate Nisha Muralidharan for receiving first and Siva Shanmugam for receiving second best poster award during 5th IITM - Tokyo Tech Joint Symposium.

08/03/2020

• 5th IITM - Tokyo Tech Joint Symposium titled "Current trends in Bioinformatics: Big data analysis, machine learning and drug design", held on 6th - 7th March 2020 in IITM, Chennai, India

21/02/2020

• Published an article "CPAD 2.0: A repository of curated experimental data on aggregating proteins and peptides". P. Rawat, R. Prabakaran, R.Sakthivel, A. Mary Thangakani, Sandeep Kumar and M. Michael Gromihaa in Amyloid.

11/02/2020

• Published an article "Molecular dynamics simulations of cognate and non-cognate AspRS-tRNA Asp complexes". C. Ramakrishnan, R. Nagarajan, M. Sekijima and M. Michael Gromiha​ in Journal of Biomolecular Structure and Dynamic.

05/02/2020

• We welcome Divya Sharma as a M.S scholar.

11/01/2020

• We congratulate Dr. P. Anoosha (Alumni) for receiving the award of Pelotonia Post-Doctoral Fellowship.

10/01/2020

• Published an article "Identifying suitable tools for variant detection and differential gene expression using RNA-seq data". Akila Parvathy Dharshini, Y-h. Taguchi and M. Michael Gromiha​ in Genomics.

18/12/2019

• Published a review "Computational approaches for identifying potential inhibitors on targeting protein interactions in drug discovery". V. Kanakaveti, A. Shanmugam, C. Ramakrishnan, P. Anoosha, R. Sakthivel, S.K. Rayala and M. Michael Gromiha in Adv. Prot. Chem. Str. Biol.

16/12/2019

• Published an article "A prospective compound screening contest identified broader inhibitors for Sirtuin 1" S. Chiba, M. Ohue, A. Gryniukova, P. Borysko, S. Zozulya, N. Yasuo, R. Yoshino, K. Ikeda, W-H. Shin, D. Kihara, M. Iwadate, H. Umeyama, T. Ichikawa, R. Teramoto, K-Y. Hsin, V. Gupta, H. Kitano, M. Sakamoto, A. Higuchi, N. Miura, K. Yura, M. Mochizuki, C. Ramakrishnan, A. Mary Thangakani, D. Velmurugan, M. Michael Gromiha, I. Nakane, N. Uchida, H. Hakariya, M. Tan, H. Nakamura, S.D. Suzuki, T. Ito, M. Kawatani, K. Kudoh, S. Takashina, K. Yamamoto, Y. Moriwaki, K. Oda, D. Kobayashi, T. Okuno, S. Minami, G. Chikenji, P. Prathipati, C. Nagao, A. Mohsen, M. Ito, K. Mizuguchi, T. Honma, T. Ishida, T. Hirokawa, Y. Akiyama and M. Sekijima in Scientific Reports.

12/12/2019

• We welcome Dr. Sujatha Roy as a SERB-TARE Fellow.

06/12/2019

• We congratulate Dr. Dhanusha Yesudhas for receiving Young Scientist Fellowship from Indian Council of Medical Research.

28/11/2019

• Published an article "Pred-MutHTP: Prediction of disease-causing and neutral mutations in human transmembrane proteins" by A. Kulandaisamy, Jan Zaucha, R. Sakthivel, Dmitrij Frishman and M. Michael Gromiha​ in Human Mutation

10/11/2019

• Published an article "Investigating the energy crisis in Alzheimer disease using transcriptome study" by S. Akila Parvathy Dharshini, Y-h. Taguchi and M. Michael Gromiha in Scientific Reports

06/11/2019

• Published an article "ProAffiMuSeq: Sequence-based method to predict the binding free energy change of protein-protein complexes upon mutation using functional classification" by Sherlyn Jemimah, Masakazu Sekijima and M. Michael Gromiha in Bioinformatics.

21/10/2019

• Prof. M. Michael Gromiha has been appointed as a Section Editor (Protein Bioinformatics) in Current Protein and Peptide Science.

20/10/2019

• Published an article " Mutational landscape of the BAP1 locus reveals an intrinsic control to regulate the miRNA network and the binding of protein complexes in uveal melanoma." A. Sharma, A. Biswas, L. Hongde, S. Sen, P. Anoosha, P. Katsonis, O. Lichtarge, T.C. Dakal, U. Maulik, M. Michael Gromiha, S. Bandyopadhyay, M. Ludwig, F.G. Holz, K.U Loeffler, M.C. Herwig-Carl in Cancers.

15/10/2019

• Dr. P. Anoosha from Ohio State University (Alumni from Protein Bioinformatics Lab) visited our lab on 15th Oct and delivered a talk.

04/10/2019

• Published an article "AggreRATE-Pred: A mathematical model for the prediction of change in aggregation rate upon point mutation." P. Rawat, R. Prabakaran, S. Kumar and M. Michael Gromiha in Bioinformatics.

13/09/2019

• Prof. M. Michael Gromiha is listed as one of the topmost 0.5% of researchers in Bioinformatics, Biophysics and overall rank by standardised citation metrics published in PLoS Biology.

05/09/2019

• We congratulate Kulandai Samy for "Initiative for Biological Systems Engineering (IBSE)" travel grant award 2019.

02/08/2019

• Prof. M. Michael Gromiha visited National Institute of Immunology, New Delhi and delivered an invited talk on Protein Interactions.

27/07/2019

• Prof. M. Michael Gromiha and Dr. Sakthivel visited St. Petersburg Polytechnic University, Russia during 23-27 July 2019 and delivered invited talks on Protein Structure and Function.

22/07/2019

• Ambuj Srivastava and Puneet Rawat presented their work in a joint conference conducted by Intelligent Systems of Molecular Biology and Europian Conference on Computational Biology (ISMB-ECCB - 2019) at Congress Center, Basel, Switzerland.

09/07/2019

• Published an article "BorodaTM: prediction of disease-associated mutations in membrane proteins with known 3D structure. " Popov P, Bizin I, A. Kulandaisamy, M. Michael Gromiha and Frishman D in PLos ONE.

28/06/2019

• Prof. Michael Gromiha, Dr. R. Sakthivel, Dr. C. Ramakrishnan, Sherlyn Jemimah, Kulandai Samy A, Prabhakaran Ram, Medha Pandey and Rahul Nikam visited the Science for Life Laboratory (SciLifeLab), Stockholm University, Sweden to attend a joint workshop between the Protein Bioinformatics Lab and SciLifeLab, during June 23-28, 2019.

16/05/2019

• Published an article "Seq2Feature: a comprehensive web-based feature extraction tool." by Rahul Nikam and M. Michael Gromiha in Bioinformatics.
• Published an article "Amarogentin, a secoiridoid glycoside, activates AMP-activated protein kinase (AMPK) to exert beneficial vasculo-metabolic effects." by P Uma Rani , K VishnuPriya, M.K.N. Sai Varsha, M Nikunj, C Shivam, N Manoj, R Thiagarajan, R Manikandan, M. Michael Gromiha and D Madhulika in BBA - General Subjects.

03/04/2019

• Published an article "Forging new scaffolds from old: Combining Scaffold hopping and Hierarchical virtual screening for identifying novel Bcl-2 inhibitors." by V. Kanakaveti, R. Sakthivel, S.K. Rayala and M. Michael Gromiha in Current Topics in Medicinal Chemistry.

25/03/2019

• Published an article "Drug repositioning for dengue hemorrhagic fever by integrating multiple omics analyses. " by T. Amemiya, M. Michael Gromiha, K. Horimoto and K. Fukui in Scientific Reports.

23/03/2019

• We congratulate Ambuj Srivastava for securing silver medal in Table Tennis competition conducted during PG League.
• We congratulate Medha Pandey for securing Gold medal and silver medal in Table Tennis competition conducted during PG League and Women's Schroeter.
• We congratulate Kulandaisamy for securing silver medal in Hockey competition conducted during Men's Schroeter.

02/03/2019

• Nisha Muralidharan has received an award for expressing her views about breaking stereotypes of kids at Taboo event held at Chennai, Tamil Nadu.

20/02/2019

• Prof. Michael Gromiha delivered an invited talk at the International Conference on Chemical and Structural Biology, PRIST University, Chennai.​

18/02/2019

• Prof. Chandra Verma from Bioinformatics Institute, A*Star, Singapore, visited our lab on 18th Feb 2019.

17/02/2019

• Prof. Yasien Sayed from University of the Witwatersrand University, Johannesburg, South Africa, visited our lab on 17th Feb 2019.

01/02/2019

• Published an article "Statistical analysis of disease-causing and neutral mutations in human membrane proteins" by A. Kulandaisamy, S. Binny Priya, R. Sakthivel, Dmitrij Frishman, and M. Michael Gromiha in PROTEINS.

• We welcome new member Nisha Muralidharan as a Junior Research Fellow.

28/01/2019

• Published an article "Molecular dynamics simulation studies on influenza A virus H5N1 complexed with sialic acid and fluorinated sialic acid." by R.A. Jeyaram , T.R.K Priyadarzini , C. Anu Radha , N.R. Siva Shanmugam , C. Ramakrishnan , M. Michael Gromiha and K. Veluraja in Journal of Biomolecular Structure and Dynamics.

23/01/2019

• Dr. Narayanan and Dr. Sudha from Stockholm University, visited our lab on 23rd Jan 2019.

22/01/2019

• Prof. Michael Gromiha delivered an invited talk at Presidency College, Chennai.

08/01/2019

• Professor Ashok Venkitaramanan from University of Cambridge, visited our lab on 8th Jan 2019.

07/01/2019

• Published an article "HuVarBase: A human variant database with comprehensive information at gene and protein levels." by K. Ganesan, A. Kulandaisamy, S. Binny Priya and M. Michael Gromiha in PLoS ONE.

27/12/2018

• Professor David Baker, Director of the Institute for Protein Design, University of Washington visited our lab on 27th Dec 2018.

26/12/2018

• Dr. Yugandhar Kumar from Cornell University (Alumni from Protein Bioinformatics Lab) delivered a talk on 26th Dec 2018.

12/12/2018

• Professor Michael Gromiha delivered an invited talk at Tokyo Institute of Technology, Japan on 12th Dec 2018.

30/11/2018

• Published an article "Structural insights into the aggregation mechanism of huntingtin exon 1 protein fragment with different polyQ-lengths." by S. Binny Priya and M. Michael Gromiha in Journal of Cellular Biochemistry.

25/11/2018

• Published an article "Influence of amino acid mutations and small molecules for targeted inhibition of proteins involved in cancer." by V. Kanakaveti, P. Anoosha, R. Sakthivel, S.K. Rayala and M. Michael Gromiha in Current Topics in Medicinal Chemistry.

15/11/2018

• Published an article "Protein structural bioinformatics: an overview" by M. Michael Gromiha, R. Nagarajan and S. Selvaraj in Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics.

30/10/2018

• Professor M. Michael Gromiha received the Tamilnadu Scientist Award (TANSA Award) in Biological Sciences for the year 2017.

12/10/2018

• Published an article "An in-silico method for identifying aggregation rate enhancer and mitigator mutations in proteins." by Puneet Rawat, Sandeep Kumar and M. Michael Gromiha in International Journal of Biological Macromolecules.

28/09/2018

• We congratulate Kulandaisamy for receiving the best poster award at 17^th International conference on Bioinformatics held at JNU, New Delhi during the period 26 - 28 September 2018.

21/09/2018

• Professor Shoba Ranganathan visited our lab on 21^st Sept 2018 and delivered an invited talk.

09/07/2018

• Sherlyn Jemimah presented a poster titled "A Computational Study of the Additivity of Binding Free Energy in Protein-Protein Complexes Upon Double Mutation" at The Protein Society's 32^nd Annual symposium held on 9 - 12 July 2018 in Boston, Massachusetts, USA.

26/06/2018

• Dharshini, S. Akila Parvathy, presented a poster titled "Identifying suitable spliced mapper and genomic assembly for variant detection" at Galaxy Community Conference and Bioinformatics Open Source Conference 2018 (GCCBOSC2018) held at Portland, Oregon, United States from 25-30 June, 2018.

04/06/2018

• Published an article "Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis" by S. Akila Parvathy Dharshini, Y-h. Taguchi and M. Michael Gromiha in Genomics.

16/05/2018

• Published an article "Deciphering RNA-Recognition Patterns of Intrinsically Disordered Proteins" by Ambuj Srivastava, Shandar Ahmad, and M. Michael Gromiha in International Journal of Molecular Sciences.
• Published an article "Identification and analysis of key residues in protein—RNA complexes" by A. Kulandaisamy, Ambuj Srivastava, Pradeep Kumar, Nagarajan Raju and Dr. M. Michael Gromiha in IEEE/ACM Transactions on Computational Biology and Bioinformatics.

10/05/2018

• We congratulate Sherlyn Jemimah for Protein Science (sponsored by Wiley) Travel Award.
• We welcome new members Dr. Dhanusha Yesudhas as a Research Associate and Priyadharshini Kannan as a Juniour Research Fellow.

02/04/2018

• We welcome new member Dr. J. Jino Blessy as a Research Associate.

15/03/2018

• We have released MutHTP, a database for Mutations in Human Transmembrane Proteins. It can be accessed here.

6/03/2018

• Published an article "Identification and analysis of key residues involved in folding and binding of protein-carbohydrate complexes. " by N.R. Siva Shanmugam, J. Fermin Angelo Selvin, K. Veluraja and M. Michael Gromiha. in Protein & Peptide Letters.

1/02/2018

• Published an article "MutHTP: Mutations in Human Transmembrane Proteins." by A. Kulandaisamy, S. Binny Priya, R. Sakthivel, S. Tarnovskaya, I. Bizin, P. Hönigschmid, D. Frishman and M. M. Gromiha in Bioinformatics.

26/01/2018

• An article "Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes" by Sherlyn Jemimah and M. Michael Gromiha has been accepted for publication in Proteins: Structure, Function, and Bioinformatics.

19/12/2017

• Published an article "Dissecting and analyzing key residues in protein-DNA complexes" by A. Kulandaisamy, A. Srivastava, R. Nagarajan, M. Michael Gromiha in Journal of Molecular Recognition.
• Conducted 1^st Indo-Sweden discussion meeting on "Protein Bioinformatics and Deep Learning" on December 10-11,2017.
• Conducted 4^th IIT Madras-Tokyo Tech Joint Symposium on "Frontiers in Bioinformatics: Large scale data analysis, Resources and Drug Design" on November 10-11, 2017.

18/07/2017

• Three "Research Associate" positions are available, for detail click here.
• Two "Junior Research Fellow" positions are available, for detail click here.

17/07/2017

• Organising 4th IITM - Tokyo Tech Joint Symposium on the topic "Frontiers in Bioinformatics: Large scale data analysis, Resources and Drug design" from 10th - 11th November 2017.

01/07/2017

• Released new lab website

16/06/2017

• Dr. S. Selvaraj from Bharathidasan University visited our lab from 14 to 16 June, 2017.

07/06/2017

• One "Research Associate" and two "Junior Research Fellow" positions are available.

05/06/2017

• Received a research grant from the Council of Scientific and Industrial Research (CSIR), Government of India under Extramural Research Division for the project "Predictive modeling of nucleic acid recognition dynamics and structured complex formation by disordered proteins" during the period 2017-2019.

20/05/2017

• Published an article "PROXiMATE: A database of mutant protein-protein complex thermodynamics and kinetics." by Sherlyn Jemimah, K. Yugandhar, M. Michael Gromiha in Bioinformatics.
• We have released PROXiMATE, a database of thermodynamic data for mutant protein heterodimer complexes collected from literature and previously published databases. It can be accessed here.

20/03/2017

• Published an article "Aggregation Propensity of Human Proteome: Insights from large-scale data analyses." by R. Prabakaran, D. Goel, S. Kumar and M. Michael Gromiha in Proteins.

25/02/2017

• Prof. Dr. Dimitrij Frishman from Technical University of Munich visited our lab from 13 to 16 Feb, 2017 under Indo-Russia bilateral research project funded by Department of Science and Technology (DST) and Russian Science Foundation (RSF).

01/02/2017

• Published a review article "Protein-protein interactions: scoring schemes and binding affinity." by M. Michael Gromiha, K. Yugandhar, and S. Jemimah (2016) in Current Opinion in Structural Biology.

25/01/2017

• Two project positions are available. Please see the details here.

06/01/2017

• Received a research grant from the Department of Science and Technology (DST), Government of India under Indo-Sweden bilateral program for the project "Deep learning for life sciences" during the period 2017-2019.

16/12/2016

• An article "Importance of functional groups in predicting the activity of small molecule inhibitors of Bcl-2 and Bcl-xL" by V. P. Kanakaveti, R. Sakthivel, Suresh K. Rayala and M. Michael Gromiha has been accepted in Chem. Biol. Drug Des. journal.
• Published an article "Analysis of protein-protein interaction networks based on binding affinity" by K. Yugandhar and M. Michael Gromiha in Current Protein & Peptide Science.
• Published an article "Important amino acid residues involved in folding and binding of protein-protein complexes" by A. Kulandaisamy, V. Lathi, K. Viswa Poorani, K. Yugandhar, and M. Michael Gromiha in International Journal of Biological Macromolecules.

29/09/2016

• Published an article "Quercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation and binding free energy calculation" by S. Anusuya and M. Michael Gromiha in Journal of Biomolecular Structure and Dynamics.