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2004
Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, et al. Therapeutic Silencing In Vivo of an Endogenous Gene by Systemic Administration of Modified siRNAs. Nature. 2004;432:173-178.