<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pandithevan, P</style></author><author><style face="normal" font="default" size="100%">Saravana Kumar, G</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Personalised bone tissue engineering scaffold with controlled architecture using fractal tool paths in layered manufacturing</style></title><secondary-title><style face="normal" font="default" size="100%">Virtual and Physical Prototyping</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">biomimetic design</style></keyword><keyword><style  face="normal" font="default" size="100%">bone replacement</style></keyword><keyword><style  face="normal" font="default" size="100%">layered manufacturing</style></keyword><keyword><style  face="normal" font="default" size="100%">porous scaffold</style></keyword><keyword><style  face="normal" font="default" size="100%">tissue engineering</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">4</style></volume><pages><style face="normal" font="default" size="100%">165 - 180</style></pages><abstract><style face="normal" font="default" size="100%">The scaffolds for bone tissue engineering should consider the functional requirements such as the external shape of the replacement, porosity for vessel and nutrient conduit, and stiffness in order to avoid stress shielding and to stimulate growth of the new tissue. Layered manufacturing (LM) has shown great promise in fabricating such porous bone scaffold. The present work proposes a biomimetic design and LM of patient- and sitespecific controlled porosity scaffolds for optimised mechanical properties for repair and regeneration of bone. Correlation models between porosity and modulus for bone, and known biomaterials processable by LM are used to estimate the site-specific porosity requirements in the scaffold model. A novel method for generating a tool path using space-filling fractal curves eliminates representation difficulties associated with LM of
porous objects. A representative study of a hydroxyapatite scaffold for a cortical bone defect site in human femur is presented to illustrate the methodology.</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue></record></records></xml>